DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGHET
Uniprot ID:
Q8NAX2
Source protein:
Keratinocyte differentiation factor 1
Source gene:
KDF1
Class:
DEG_SCF_TRCP1_1
Location:
332:337
E3 ligase:
BTRC
DEGRON score:
0.9745
ASA_SCORE:
68.3
COIL:
0.63
CONS_SCORE:
0.8208
DSS_SCORE:
0.6775
HELIX:
0.2208
FCONS_SCORE:
1.5575
RIG_SCORE:
0.6124
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KDF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGHET
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NAX2
Keratinocyte differentiation factor 1
DEG_SCF_TRCP1_1
332:337
DSGHET
BTRC
0.9745
More...
Q5JV73
FERM and PDZ domain-containing protein 3
DEG_SCF_TRCP1_1
802:807
DSGHET
BTRC
0.5205
More...