DegronMD

Uniprot ID: Q5JV73

Source protein: FERM and PDZ domain-containing protein 3

Source gene: FRMPD3

Class: DEG_SPOP_SBC_1

Location: 1230:1234

E3 ligase: SPOP

DEGRON score: 0.9223

ASA_SCORE: 92.92

COIL: 0.9436

CONS_SCORE: 0.3063

DSS_SCORE: 0.7232

HELIX: 0.0314

FCONS_SCORE: 1.1129

RIG_SCORE: 0.59

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1243F	TCGA-90-A4ED	LUSC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.0833
p.S1243F	DO45482	LUSC	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E1224D	TCGA-AX-A1CE	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.1667
p.E1224D	DO42280	UCEC	ICGC	AHSTS	DEG_SPOP_SBC_1	0.1667
p.S1234C	TCGA-NH-A6GB	COAD	TCGA	AHSTS	DEG_SPOP_SBC_1	0.7541
p.S1234C	DO50092	COAD	ICGC	AHSTS	DEG_SPOP_SBC_1	0.7541
p.S1242L	SIDM01141	Ovarian Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1242L	SIDM01649	Non-Cancerous	GDSC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1242L	SIDM00184	Melanoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1242L	ACH-000291	Ovarian Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1242L	ACH-001022	Bone Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1242L	ACH-002355	Non-Cancerous	CCLE	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S1232L	SIDM01177	B-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	0.7667
p.S1232L	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.7667
p.N1228S	ACH-000160	Rhabdoid	CCLE	AHSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons