DegronMD - Q5T8A7(PPP1R26)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T418N	TCGA-02-2486	GBM	TCGA	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0556
p.T418N	DO11866	GBM	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0556
p.R395Q	TCGA-10-0933	OV	TCGA	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.R395Q	DO29358	OV	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.A95V	TCGA-AX-A2HD	UCEC	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.25
p.A95V	TCGA-XF-A8HG	BLCA	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.25
p.A95V	DO49802	BLCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.25
p.A95V	DO42608	UCEC	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.25
p.P931H	TCGA-BF-A1PZ	SKCM	TCGA	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1111
p.P931H	DO50279	SKCM	ICGC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1111
p.E417K	TCGA-BG-A221	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.E417K	DO42384	UCEC	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.C78R	TCGA-CG-5721	STAD	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1111
p.C78R	DO38192	STAD	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1111
p.V1206A	TCGA-DI-A1BU	UCEC	TCGA	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.3056
p.V1206A	DO42023	UCEC	ICGC	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.3056
p.P402H	TCGA-DK-A2I1	BLCA	TCGA	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.P402H	DO444	BLCA	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.R955M	TCGA-DU-6392	LGG	TCGA	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.25
p.R955M	DO22237	LGG	ICGC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.25
p.L101I	TCGA-VQ-A923	STAD	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0833
p.L101I	DO222361	STAD	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0833
p.H90R	TCGA-ZF-A9RC	BLCA	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation altering degron motif	0.8244
p.H90R	DO219068	BLCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation altering degron motif	0.8244
p.P936L	DO224689	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P403T	DO222503	COCA	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.A948T	DO52439	COCA	ICGC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1944
p.A948T	DO52439	COCA	ICGC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.0556
p.D1192G	DO222856	COCA	ICGC	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.1111
p.V98A	DO229013	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.V98A	DO229016	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.V98A	DO229005	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.V98A	DO229489	LAML	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.P83L	DO233199	GACA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.25
p.V960F	DO229034	LICA	ICGC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.7068
p.E1199D	DO229006	LICA	ICGC	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.3056
p.T407K	DO229006	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7306
p.T407K	SIDM00636	Non-Cancerous	GDSC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7306
p.T407K	ACH-002270	Non-Cancerous	CCLE	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7306
p.T407K	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7306
p.V960I	DO23492	LINC	ICGC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5965
p.G945C	DO231149	LUSC	ICGC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2778
p.H961Y	DO220887	MELA	ICGC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.6118
p.T1198M	DO29308	OV	ICGC	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.2778
p.V89M	DO229259	THCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation altering degron motif	0.6097
p.A410V	DO229257	THCA	ICGC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.V102L	DO229250	THCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0556
p.V958I	SIDM00373	Endometrial Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5965
p.V958I	ACH-000974	Endometrial/Uterine Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5965
p.A81T	SIDM00395	Neuroblastoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM00623	Other Blood Cancers	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM00211	B-Lymphoblastic Leukemia	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM00966	Ovarian Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.A81T	SIDM01696	Mesothelioma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1944
p.G944S	SIDM00557	Neuroblastoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.G944S	SIDM00075	Non-Cancerous	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.G944S	SIDM00362	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.G944S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.G944S	SIDM01695	Acute Myeloid Leukemia	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.H405Y	SIDM00845	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6118
p.H405Y	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.6118
p.P938L	SIDM00845	Burkitt's Lymphoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.P938L	SIDM01147	Gastric Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.3056
p.A84P	SIDM00336	Melanoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2778
p.L96F	SIDM00523	Small Cell Lung Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.L96F	ACH-000698	Lung Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.L96F	DMS-53	lung	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.D935N	SIDM00806	Osteosarcoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2222
p.D935N	HOS	bone	COSMIC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2222
p.A973T	SIDM00251	Gastric Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.0556
p.A973T	ACH-000949	Gastric Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.0556
p.A973T	TGBC11TKB	stomach	COSMIC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.0556
p.R82G	SIDM00537	Colorectal Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.R82G	ACH-000982	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.R82G	ACH-001345	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.R82G	GP5d	large intestine	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.2222
p.V102I	SIDM00537	Colorectal Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0556
p.V102I	ACH-000982	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0556
p.V102I	ACH-001345	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0556
p.V102I	GP5d	large intestine	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.0556
p.K962N	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5806
p.K962N	ACH-000951	Lung Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5806
p.K962N	NCI-H2342	lung	COSMIC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation altering degron motif	0.5806
p.A404V	SIDM00217	Colorectal Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.5825
p.A404V	ACH-000999	Colon/Colorectal Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.5825
p.A404V	SNU-1040	large intestine	COSMIC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.5825
p.E417G	SIDM00980	Gastric Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.E417G	23132-87	stomach	COSMIC	AHSTS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.0833
p.D80G	SIDM01608	Endometrial Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.D80G	ACH-000990	Endometrial/Uterine Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	86:92	Mutation rewiring degron network	0.1667
p.G950E	SIDM01520	Oral Cavity Carcinoma	GDSC	PRSTS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1389
p.G950E	SIDM01520	Oral Cavity Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.1111
p.V1206L	ACH-000634	Brain Cancer	CCLE	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation rewiring degron network	0.3056
p.G1202V	ACH-000851	Lung Cancer	CCLE	DSGGSS	DEG_SCF_TRCP1_1	1200:1205	Mutation altering degron motif	0.7532
p.E970Q	ACH-001522	Skin Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	958:963	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R26

UniProt ID: Q5T8A7

Entrez ID: 9858

Protein name: Protein phosphatase 1 regulatory subunit 26

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R26 in