DegronMD

Uniprot ID: Q5T8A7

Source protein: Protein phosphatase 1 regulatory subunit 26

Source gene: PPP1R26

Class: LIG_APCC_ABBA_1

Location: 958:963

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7341

ASA_SCORE: 114.9

COIL: 0.8978

CONS_SCORE: 0.3687

DSS_SCORE: 0.585

HELIX: 0.0603

FCONS_SCORE: 0.9977

RIG_SCORE: 0.7572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R955M	TCGA-DU-6392	LGG	TCGA	VYVHKD	LIG_APCC_ABBA_1	0.25
p.R955M	DO22237	LGG	ICGC	VYVHKD	LIG_APCC_ABBA_1	0.25
p.A948T	DO52439	COCA	ICGC	VYVHKD	LIG_APCC_ABBA_1	0.0556
p.V960F	DO229034	LICA	ICGC	VYVHKD	LIG_APCC_ABBA_1	0.7068
p.V960I	DO23492	LINC	ICGC	VYVHKD	LIG_APCC_ABBA_1	0.5965
p.H961Y	DO220887	MELA	ICGC	VYVHKD	LIG_APCC_ABBA_1	0.6118
p.V958I	SIDM00373	Endometrial Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	0.5965
p.V958I	ACH-000974	Endometrial/Uterine Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	0.5965
p.A973T	SIDM00251	Gastric Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	0.0556
p.A973T	ACH-000949	Gastric Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	0.0556
p.A973T	TGBC11TKB	stomach	COSMIC	VYVHKD	LIG_APCC_ABBA_1	0.0556
p.K962N	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	0.5806
p.K962N	ACH-000951	Lung Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	0.5806
p.K962N	NCI-H2342	lung	COSMIC	VYVHKD	LIG_APCC_ABBA_1	0.5806
p.G950E	SIDM01520	Oral Cavity Carcinoma	GDSC	VYVHKD	LIG_APCC_ABBA_1	0.1111
p.E970Q	ACH-001522	Skin Cancer	CCLE	VYVHKD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	LIG_APCC_ABBA_1	958:963	VYVHKD	APC,CDC20,FZR1	0.7341	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons