DegronMD

Uniprot ID: Q5T8A7

Source protein: Protein phosphatase 1 regulatory subunit 26

Source gene: PPP1R26

Class: LIG_APCC_ABBAyCdc20_2

Location: 86:92

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5255

ASA_SCORE: 112.1143

COIL: 0.8886

CONS_SCORE: 0.428

DSS_SCORE: 0.5144

HELIX: 0.0203

FCONS_SCORE: 0.9014

RIG_SCORE: 0.6623

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A95V	TCGA-AX-A2HD	UCEC	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A95V	TCGA-XF-A8HG	BLCA	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A95V	DO49802	BLCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.A95V	DO42608	UCEC	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.C78R	TCGA-CG-5721	STAD	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.C78R	DO38192	STAD	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L101I	TCGA-VQ-A923	STAD	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L101I	DO222361	STAD	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H90R	TCGA-ZF-A9RC	BLCA	TCGA	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.H90R	DO219068	BLCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.V98A	DO229013	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V98A	DO229016	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V98A	DO229005	COCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V98A	DO229489	LAML	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P83L	DO233199	GACA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.V89M	DO229259	THCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.6097
p.V102L	DO229250	THCA	ICGC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A81T	SIDM00395	Neuroblastoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM00623	Other Blood Cancers	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM00211	B-Lymphoblastic Leukemia	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM00966	Ovarian Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	SIDM01696	Mesothelioma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A84P	SIDM00336	Melanoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L96F	SIDM00523	Small Cell Lung Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L96F	ACH-000698	Lung Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L96F	DMS-53	lung	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R82G	SIDM00537	Colorectal Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R82G	ACH-000982	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R82G	ACH-001345	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R82G	GP5d	large_intestine	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V102I	SIDM00537	Colorectal Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V102I	ACH-000982	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V102I	ACH-001345	Colon/Colorectal Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V102I	GP5d	large_intestine	COSMIC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D80G	SIDM01608	Endometrial Carcinoma	GDSC	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D80G	ACH-000990	Endometrial/Uterine Cancer	CCLE	KPTVHKE	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPTVHKE

Degron related mutations and impact score

Drug responses associated with PPP1R26 mutations

All proteins holding degron of KPTVHKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	LIG_APCC_ABBAyCdc20_2	86:92	KPTVHKE	APC,CDC20,FZR1	0.5255	More...