DegronMD

Uniprot ID: Q5T8A7

Source protein: Protein phosphatase 1 regulatory subunit 26

Source gene: PPP1R26

Class: DEG_SPOP_SBC_1

Location: 404:408

E3 ligase: SPOP

DEGRON score: 0.5117

ASA_SCORE: 91.36

COIL: 0.9112

CONS_SCORE: 0.3427

DSS_SCORE: 0.8085

HELIX: 0.0562

FCONS_SCORE: 0.8251

RIG_SCORE: 0.5412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T418N	TCGA-02-2486	GBM	TCGA	AHSTS	DEG_SPOP_SBC_1	0.0556
p.T418N	DO11866	GBM	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0556
p.R395Q	TCGA-10-0933	OV	TCGA	AHSTS	DEG_SPOP_SBC_1	0.0833
p.R395Q	DO29358	OV	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E417K	TCGA-BG-A221	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E417K	DO42384	UCEC	ICGC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.P402H	TCGA-DK-A2I1	BLCA	TCGA	AHSTS	DEG_SPOP_SBC_1	0.2778
p.P402H	DO444	BLCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.P403T	DO222503	COCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.3056
p.T407K	DO229006	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.7306
p.T407K	SIDM00636	Non-Cancerous	GDSC	AHSTS	DEG_SPOP_SBC_1	0.7306
p.T407K	ACH-002270	Non-Cancerous	CCLE	AHSTS	DEG_SPOP_SBC_1	0.7306
p.T407K	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.7306
p.A410V	DO229257	THCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2778
p.H405Y	SIDM00845	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.6118
p.H405Y	ACH-000786	Lymphoma	CCLE	AHSTS	DEG_SPOP_SBC_1	0.6118
p.A404V	SIDM00217	Colorectal Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.5825
p.A404V	ACH-000999	Colon/Colorectal Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.5825
p.A404V	SNU-1040	large_intestine	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.5825
p.E417G	SIDM00980	Gastric Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.E417G	23132-87	stomach	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons