DegronMD

Uniprot ID: Q58WW2

Source protein: DDB1- and CUL4-associated factor 6

Source gene: DCAF6

Class: DEG_SPOP_SBC_1

Location: 421:425

E3 ligase: SPOP

DEGRON score: 0.5333

ASA_SCORE: 85.58

COIL: 0.816

CONS_SCORE: 0.2893

DSS_SCORE: 0.7834

HELIX: 0.1634

FCONS_SCORE: 1.0135

RIG_SCORE: 0.5225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q420H	TCGA-BF-A1Q0	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	0.3056
p.Q420H	DO47374	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	0.3056
p.Q420E	TCGA-C5-A1MN	CESC	TCGA	AHSTS	DEG_SPOP_SBC_1	0.3056
p.Q420E	TCGA-D8-A1JA	BRCA	TCGA	AHSTS	DEG_SPOP_SBC_1	0.3056
p.Q420E	DO2819	BRCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.3056
p.Q420E	DO6257	CESC	ICGC	AHSTS	DEG_SPOP_SBC_1	0.3056
p.S433F	TCGA-EE-A29B	SKCM	TCGA	AHSTS	DEG_SPOP_SBC_1	0.1111
p.S433F	DO47255	SKCM	ICGC	AHSTS	DEG_SPOP_SBC_1	0.1111
p.H422R	DO228920	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.7133
p.E429K	DO229542	UTCA	ICGC	AHSTS	DEG_SPOP_SBC_1	0.2222
p.T434I	ACH-001061	Colon/Colorectal Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons