DegronMD - Q12816(TRO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1350K	TCGA-06-5416	GBM	TCGA	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.3056
p.E1350K	SIDM00945	Colorectal Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.3056
p.E1350K	ACH-000895	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.3056
p.E1350K	CL-34	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.3056
p.S800I	TCGA-2Y-A9GZ	LIHC	TCGA	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.7341
p.S800I	TCGA-AX-A06F	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.7341
p.D735N	TCGA-39-5016	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.0833
p.D735N	DO26701	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.0833
p.A773D	TCGA-49-AARE	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.S768I	TCGA-A5-A1OF	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2778
p.S768I	DO42568	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2778
p.G920S	TCGA-A5-A2K5	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.25
p.G920S	DO231673	LINC	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.25
p.G920S	DO41379	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.25
p.T1355M	TCGA-AX-A2HC	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation altering degron motif	0.7423
p.S788G	TCGA-BR-4368	STAD	TCGA	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.S788G	DO38715	STAD	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.G1250S	TCGA-D1-A17B	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.P755H	TCGA-D1-A17Q	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.P755H	TCGA-D1-A17Q	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.P755H	DO41903	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.P755H	DO41903	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.P755H	SIDM01019	Acute Myeloid Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.P755H	SIDM01019	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.P755H	ACH-002258	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.P755H	ACH-002258	Leukemia	CCLE	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.P755H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.P755H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.1389
p.G1250C	TCGA-EE-A2MD	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.G1250C	DO37851	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.G1258A	TCGA-G4-6625	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.3056
p.G1258A	DO9266	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.3056
p.S749C	DO219637	BRCA	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.3056
p.S748N	DO222895	BTCA	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7069
p.G915C	DO230342	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.S1341F	DO233263	GACA	ICGC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.0556
p.T798P	DO11166	GBM	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.7031
p.G796V	DO228978	LICA	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.G915V	DO229018	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.G915V	DO220007	SARC	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.S929I	DO229026	LICA	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2778
p.A737S	DO229034	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1389
p.S1362I	DO229034	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1389
p.S1362I	DO46453	OV	ICGC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1389
p.G1262V	DO229045	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1944
p.G1262V	SIDM00457	Plasma Cell Myeloma	GDSC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1944
p.G1262V	ACH-000024	Myeloma	CCLE	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1944
p.G1262V	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1944
p.P1361S	DO45299	LIRI	ICGC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1667
p.G736D	DO229177	LMS	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1111
p.S807R	DO24070	LUAD	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1944
p.D931E	DO26608	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2222
p.D931E	DO27381	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2222
p.L750I	DO27067	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.2778
p.S812I	DO46488	OV	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.0556
p.D792E	DO229453	SKCA	ICGC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1667
p.S764T	DO37667	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation altering degron motif	0.6005
p.S738I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1667
p.S738I	ACH-000636	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.1667
p.G1254D	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6087
p.G1254D	ACH-000795	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6087
p.G1254D	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6087
p.T1345N	SIDM00845	Burkitt's Lymphoma	GDSC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation blocking phosphorylation signal	0.6111
p.S734R	SIDM00614	Hepatocellular Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.0556
p.S734R	ACH-000848	Liver Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.0556
p.S734R	JHH-7	liver	COSMIC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation rewiring degron network	0.0556
p.S747F	SIDM00848	Ewing's Sarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7982
p.S747F	SIDM00699	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7982
p.S747F	ACH-001138	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	744:748	Mutation altering degron motif	0.7982
p.H799P	SIDM00656	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM00087	Plasma Cell Myeloma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM00863	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM00720	Mesothelioma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM00785	Acute Myeloid Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM00641	Burkitt's Lymphoma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.H799P	SIDM01640	Acute Myeloid Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.6583
p.T935A	SIDM00193	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.T935A	ACH-000991	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.T935A	SNU-81	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1111
p.S1363C	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1111
p.S1363C	ACH-000488	Esophageal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1111
p.S1363C	TE-11	oesophagus	COSMIC	PSTST	DEG_SPOP_SBC_1	1351:1355	Mutation rewiring degron network	0.1111
p.S806I	SIDM00687	Gastric Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.S806I	ACH-000793	Gastric Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.S806I	KATOIII	stomach	COSMIC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.S800N	SIDM01617	Endometrial Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.7069
p.S800N	ACH-000994	Endometrial/Uterine Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation altering degron motif	0.7069
p.A791T	ACH-001991	Primary	CCLE	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1389
p.P926L	OE19	oesophagus	COSMIC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.7582
p.L804M	NCI-H1417	lung	COSMIC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2778
p.P921L	SK-MEL-30	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2778
p.T806I	SW1271	lung	COSMIC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.2222
p.G793V	OPM-2	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	798:802	Mutation rewiring degron network	0.1944
p.L760I	A549	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.2778
p.S761G	HN	upper aerodigestive tract	COSMIC	APSTS	DEG_SPOP_SBC_1	762:766	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRO

UniProt ID: Q12816

Entrez ID: 7216

Protein name: Trophinin (MAGE-D3 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRO in