DegronMD

Uniprot ID: Q12816

Source protein: Trophinin

Source gene: TRO

Class: DEG_SPOP_SBC_1

Location: 1253:1257

E3 ligase: SPOP

DEGRON score: 0.5326

ASA_SCORE: 75.96

COIL: 0.865

CONS_SCORE: 0.439

DSS_SCORE: 0.443

HELIX: 0.031

FCONS_SCORE: 0.8162

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1250S	TCGA-D1-A17B	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.G1250C	TCGA-EE-A2MD	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.G1250C	DO37851	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.G1258A	TCGA-G4-6625	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.3056
p.G1258A	DO9266	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.G1262V	DO229045	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.G1262V	SIDM00457	Plasma Cell Myeloma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1944
p.G1262V	ACH-000024	Myeloma	CCLE	PGTST	DEG_SPOP_SBC_1	0.1944
p.G1262V	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1944
p.G1254D	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	0.6087
p.G1254D	ACH-000795	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	0.6087
p.G1254D	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with TRO mutations

All proteins holding degron of PGTST