DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGTST
Uniprot ID:
Q9BZA0
Source protein:
Putative transcript Y 10 protein
Source gene:
TTTY10
Class:
DEG_SPOP_SBC_1
Location:
39:43
E3 ligase:
SPOP
DEGRON score:
0.938
ASA_SCORE:
63.72
COIL:
0.8578
CONS_SCORE:
0
DSS_SCORE:
0.2804
HELIX:
0.0592
FCONS_SCORE:
0
RIG_SCORE:
0.6783
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TTTY10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15178
T-box transcription factor T
DEG_SPOP_SBC_1
249:253
PGTST
SPOP
0.9835
More...
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
1981:1985
PGTST
SPOP
0.9944
More...
O95255
ATP-binding cassette sub-family C member 6
DEG_SPOP_SBC_1
867:871
PGTST
SPOP
0.7523
More...
P02751
Fibronectin
DEG_SPOP_SBC_1
2242:2246
PGTST
SPOP
0.9855
More...
P24592
Insulin-like growth factor-binding protein 6
DEG_SPOP_SBC_1
141:145
PGTST
SPOP
0.9935
More...
Q04726
Transducin-like enhancer protein 3
DEG_SPOP_SBC_1
329:333
PGTST
SPOP
0.9981
More...
Q12816
Trophinin
DEG_SPOP_SBC_1
1253:1257
PGTST
SPOP
0.5326
More...
Q2KHR2
DNA-binding protein RFX7
DEG_SPOP_SBC_1
514:518
PGTST
SPOP
0.9981
More...
Q5VST9
Obscurin
DEG_SPOP_SBC_1
212:216
PGTST
SPOP
0.5286
More...
Q8NAP3
Zinc finger and BTB domain-containing protein 38
DEG_SPOP_SBC_1
825:829
PGTST
SPOP
0.7458
More...
Q8WWQ0
PH-interacting protein
DEG_SPOP_SBC_1
1293:1297
PGTST
SPOP
0.8833
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12203:12207
PGTST
SPOP
0.9874
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12359:12363
PGTST
SPOP
0.8271
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12517:12521
PGTST
SPOP
0.5411
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12828:12832
PGTST
SPOP
0.9788
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
12984:12988
PGTST
SPOP
0.9729
More...
Q96PU4
E3 ubiquitin-protein ligase UHRF2
DEG_SPOP_SBC_1
81:85
PGTST
SPOP
0.9892
More...
Q96QS3
Homeobox protein ARX
DEG_SPOP_SBC_1
553:557
PGTST
SPOP
0.979
More...
Q96RK0
Protein capicua homolog
DEG_SPOP_SBC_1
868:872
PGTST
SPOP
0.9813
More...
Q9H4F8
SPARC-related modular calcium-binding protein 1
DEG_SPOP_SBC_1
281:285
PGTST
SPOP
0.8861
More...
Q496Y0
LON peptidase N-terminal domain and RING finger protein 3
DEG_SPOP_SBC_1
60:64
PGTST
SPOP
0.9986
More...
Q86X27
Ras-specific guanine nucleotide-releasing factor RalGPS2
DEG_SPOP_SBC_1
286:290
PGTST
SPOP
0.9983
More...
Q96G46
tRNA-dihydrouridine
DEG_SPOP_SBC_1
269:273
PGTST
SPOP
0.9172
More...
Q9BZA0
Putative transcript Y 10 protein
DEG_SPOP_SBC_1
39:43
PGTST
SPOP
0.938
More...