DegronMD

Uniprot ID: Q04726

Source protein: Transducin-like enhancer protein 3

Source gene: TLE3

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 70.36

COIL: 0.922

CONS_SCORE: 0.4504

DSS_SCORE: 0.8255

HELIX: 0.0254

FCONS_SCORE: 0.9938

RIG_SCORE: 0.5593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S339L	TCGA-B7-5816	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1667
p.S339L	TCGA-FI-A2D0	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1667
p.S339L	DO38599	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.S339L	DO43891	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.P341R	TCGA-C8-A134	BRCA	TCGA	PGTST	DEG_SPOP_SBC_1	0.1111
p.P341R	DO1316	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.A320T	DO9788	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.A320T	DO41331	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.L337I	DO228948	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.T333K	DO229022	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.8417
p.T333K	DO229008	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.8417
p.A326V	DO220854	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.P341T	DO27899	ORCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.A340T	DO42969	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.D325G	SIDM01090	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2222
p.D325G	ACH-000943	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.D325G	RKO	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2222
p.P341Q	SIDM00411	Pancreatic Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1111
p.P341Q	ACH-000332	Pancreatic Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1111
p.P341Q	YAPC	pancreas	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1111
p.P329L	ACH-001566	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.7582
p.P334Q	YAPC	pancreas	COSMIC	PGTST	DEG_SPOP_SBC_1	0.75
p.D331G	RKO	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.7198
p.D330G	RKO	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.7198
p.D335G	RKO	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2778
p.I343L	MFE-296	endometrium	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1667
p.D329Y	NCI-H2009	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with TLE3 mutations

All proteins holding degron of PGTST