DegronMD - Q8NAP3(ZBTB38)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A335T	TCGA-37-4130	LUSC	TCGA	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7139
p.A335T	DO26490	LUSC	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7139
p.P338S	TCGA-CK-4951	COAD	TCGA	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.5641
p.V337I	TCGA-EE-A20C	SKCM	TCGA	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7076
p.V337I	DO222775	MELA	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7076
p.V337I	DO47665	SKCM	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7076
p.I815V	TCGA-N5-A4RT	UCS	TCGA	PGTST	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.0556
p.P338L	TCGA-VS-A9UL	CESC	TCGA	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.6471
p.A334V	TCGA-YD-A9TA	SKCM	TCGA	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.5825
p.P339L	DO51643	CESC	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7582
p.P339S	DO10582	COAD	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.6752
p.S346G	DO230343	COCA	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation rewiring degron network	0.1667
p.D328G	DO50320	ESAD	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation rewiring degron network	0.2222
p.P333L	DO233859	GACA	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.7582
p.L836F	DO220906	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1389
p.A335V	DO219503	SKCM	ICGC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation altering degron motif	0.6936
p.N343T	SIDM00049	Colorectal Carcinoma	GDSC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation rewiring degron network	0.25
p.N343T	ACH-002233	Colon/Colorectal Cancer	CCLE	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation rewiring degron network	0.25
p.N343T	DIFI	large intestine	COSMIC	PPAAEVPPL	DEG_SIAH_1	332:340	Mutation rewiring degron network	0.25

Kaplan plot for ZBTB38 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB38

UniProt ID: Q8NAP3

Entrez ID: 253461

Protein name: Zinc finger and BTB domain-containing protein 38

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB38 in