DegronMD

Uniprot ID: Q8NAP3

Source protein: Zinc finger and BTB domain-containing protein 38

Source gene: ZBTB38

Class: DEG_SIAH_1

Location: 332:340

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9763

ASA_SCORE: 72.3889

COIL: 0.7259

CONS_SCORE: 0.5521

DSS_SCORE: 0.3992

HELIX: 0.0109

FCONS_SCORE: 0.9336

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A335T	TCGA-37-4130	LUSC	TCGA	PPAAEVPPL	DEG_SIAH_1	0.7139
p.A335T	DO26490	LUSC	ICGC	PPAAEVPPL	DEG_SIAH_1	0.7139
p.P338S	TCGA-CK-4951	COAD	TCGA	PPAAEVPPL	DEG_SIAH_1	0.5641
p.V337I	TCGA-EE-A20C	SKCM	TCGA	PPAAEVPPL	DEG_SIAH_1	0.7076
p.V337I	DO222775	MELA	ICGC	PPAAEVPPL	DEG_SIAH_1	0.7076
p.V337I	DO47665	SKCM	ICGC	PPAAEVPPL	DEG_SIAH_1	0.7076
p.P338L	TCGA-VS-A9UL	CESC	TCGA	PPAAEVPPL	DEG_SIAH_1	0.6471
p.A334V	TCGA-YD-A9TA	SKCM	TCGA	PPAAEVPPL	DEG_SIAH_1	0.5825
p.P339L	DO51643	CESC	ICGC	PPAAEVPPL	DEG_SIAH_1	0.7582
p.P339S	DO10582	COAD	ICGC	PPAAEVPPL	DEG_SIAH_1	0.6752
p.S346G	DO230343	COCA	ICGC	PPAAEVPPL	DEG_SIAH_1	0.1667
p.D328G	DO50320	ESAD	ICGC	PPAAEVPPL	DEG_SIAH_1	0.2222
p.P333L	DO233859	GACA	ICGC	PPAAEVPPL	DEG_SIAH_1	0.7582
p.A335V	DO219503	SKCM	ICGC	PPAAEVPPL	DEG_SIAH_1	0.6936
p.N343T	SIDM00049	Colorectal Carcinoma	GDSC	PPAAEVPPL	DEG_SIAH_1	0.25
p.N343T	ACH-002233	Colon/Colorectal Cancer	CCLE	PPAAEVPPL	DEG_SIAH_1	0.25
p.N343T	DIFI	large_intestine	COSMIC	PPAAEVPPL	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SIAH_1	332:340	PPAAEVPPL	SIAH1,SIAH2,SIAH3	0.9763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons