DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12828:12832

E3 ligase: SPOP

DEGRON score: 0.9788

ASA_SCORE: 67.56

COIL: 0.8576

CONS_SCORE: 0

DSS_SCORE: 0.6514

HELIX: 0.0294

FCONS_SCORE: 0

RIG_SCORE: 0.633

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P12828L	TCGA-19-5956	GBM	TCGA	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12828L	DO13863	GBM	ICGC	PGTST	DEG_SPOP_SBC_1	0.7582
p.T12837A	TCGA-4W-AA9R	GBM	TCGA	PGTST	DEG_SPOP_SBC_1	0.1944
p.T12837A	DO219107	GBM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.S12838A	TCGA-55-8089	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1667
p.S12838A	DO23690	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.G12829W	TCGA-86-8673	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.6714
p.G12829W	DO26260	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.6714
p.P12828H	TCGA-AJ-A3EL	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.7694
p.P12828H	DO227531	PACA	ICGC	PGTST	DEG_SPOP_SBC_1	0.7694
p.P12828H	DO41542	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.7694
p.T12820P	TCGA-BR-8680	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1111
p.T12820P	DO47769	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.S12831F	TCGA-D3-A3C3	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.7982
p.S12831F	DO47667	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.7982
p.S12821C	TCGA-DG-A2KK	CESC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.S12821C	DO51595	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.Q12819E	TCGA-DR-A0ZM	CESC	TCGA	PGTST	DEG_SPOP_SBC_1	0.0833
p.Q12819E	DO6254	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.G12836W	TCGA-EE-A20C	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2222
p.G12836W	DO47665	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.L12835R	TCGA-F5-6814	READ	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.L12835R	DO36556	READ	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.L12835F	DO45131	LIRI	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.D12834G	DO228371	MALY	ICGC	PGTST	DEG_SPOP_SBC_1	0.2778
p.D12834G	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2778
p.D12834G	ACH-000315	Lymphoma	CCLE	PGTST	DEG_SPOP_SBC_1	0.2778
p.D12834G	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2778
p.A12822V	SIDM00993	Plasma Cell Myeloma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1667
p.A12822V	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1667
p.H12818R	SIDM01012	Other Blood Cancers	GDSC	PGTST	DEG_SPOP_SBC_1	0.0556
p.H12818R	ACH-000346	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	0.0556
p.H12818R	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PGTST