DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12984:12988

E3 ligase: SPOP

DEGRON score: 0.9729

ASA_SCORE: 70.96

COIL: 0.8752

CONS_SCORE: 0

DSS_SCORE: 0.5858

HELIX: 0.0344

FCONS_SCORE: 0

RIG_SCORE: 0.6327

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R12975W	TCGA-96-A4JK	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.0833
p.R12975W	DO45442	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.R12975W	SIDM00632	Non-Cancerous	GDSC	PGTST	DEG_SPOP_SBC_1	0.0833
p.R12975W	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.0833
p.S12977F	TCGA-BR-8484	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.S12977F	DO222837	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.S12977F	DO48024	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.R12975Q	TCGA-BR-A4CQ	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.0833
p.R12975Q	DO47861	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.L12991R	TCGA-CG-5724	STAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.L12991R	DO38847	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.T12993S	TCGA-CV-7248	HNSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1944
p.T12993S	DO14806	HNSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.P12997L	TCGA-EE-A2GO	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.0833
p.P12997L	DO37823	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.G12992V	TCGA-EE-A2GT	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2222
p.G12992V	DO37946	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.G12995E	TCGA-EE-A2MC	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	DO228825	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	DO222426	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	DO37559	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	SIDM00140	Melanoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	ACH-000968	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995E	COLO-792	skin	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995W	TCGA-EI-6917	READ	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12995W	DO36881	READ	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.P12984S	TCGA-VS-A9U5	CESC	TCGA	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12984S	DO51641	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12984S	SIDM01198	Burkitt's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12984S	ACH-000567	Lymphoma	CCLE	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12984S	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.6752
p.L12991F	DO228202	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.T12993I	DO229177	LMS	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.D12990N	DO218884	SKCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.2778
p.P12984L	SIDM00931	Thyroid Gland Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12984L	SIDM00861	Ovarian Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12984L	ACH-000174	Thyroid Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12984L	ACH-000906	Ovarian Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12984L	CAL-62	thyroid	COSMIC	PGTST	DEG_SPOP_SBC_1	0.7582
p.P12984L	ES-2	ovary	COSMIC	PGTST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PGTST