DegronMD

Uniprot ID: P24592

Source protein: Insulin-like growth factor-binding protein 6

Source gene: IGFBP6

Class: DEG_SPOP_SBC_1

Location: 141:145

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 82.14

COIL: 0.9422

CONS_SCORE: 0.6223

DSS_SCORE: 0.9071

HELIX: 0.0192

FCONS_SCORE: 1.3476

RIG_SCORE: 0.5031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G142D	TCGA-AX-A06F	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.6087
p.S152Y	TCGA-BS-A0UF	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.R139K	TCGA-EB-A6R0	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2778
p.A153T	TCGA-YL-A8SB	PRAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1111
p.A151T	DO11854	GBM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.A151T	DO51426	PRAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.R137K	DO220887	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.R137K	DO48646	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.V153A	DO46438	OV	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.V153F	DO46438	OV	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.G140D	DO41752	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.S150Y	DO41488	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.S148F	SIDM00790	Non-Cancerous	GDSC	PGTST	DEG_SPOP_SBC_1	0.25
p.S148F	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.25
p.P141S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	0.6752
p.P141S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.6752
p.D136G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	0.1944
p.D155N	ACH-000522	Bladder Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.0556
p.D155N	UM-UC-3	urinary_tract	COSMIC	PGTST	DEG_SPOP_SBC_1	0.0556
p.D134G	ACH-000942	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	0.1389
p.P150S	ACH-000995	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	0.1944
p.P139S	ACH-001127	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	0.2778
p.P139S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with IGFBP6 mutations

All proteins holding degron of PGTST