DegronMD - Q2KHR2(RFX7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N872D	TCGA-21-1080	LUSC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation rewiring degron network	0.0556
p.N872D	TCGA-21-1080	LUSC	TCGA	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation rewiring degron network	0.2222
p.Q1087L	TCGA-44-A479	LUAD	TCGA	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.0833
p.H928L	TCGA-66-2757	LUSC	TCGA	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.25
p.P436R	TCGA-85-8354	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.N845H	TCGA-A5-A2K5	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation rewiring degron network	0.2778
p.N845H	TCGA-A5-A2K5	UCEC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation rewiring degron network	0.0556
p.T1194N	TCGA-A6-2675	COAD	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2222
p.S515F	TCGA-AA-A010	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7982
p.S518L	TCGA-AJ-A3BH	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7667
p.T448A	TCGA-AP-A1DK	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.7139
p.S1191Y	TCGA-AP-A1DV	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.3056
p.S1191Y	TCGA-EO-A22T	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.3056
p.S851Y	TCGA-AX-A05Z	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.712
p.S851Y	TCGA-B5-A11E	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.712
p.G388D	TCGA-AX-A06F	UCEC	TCGA	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.7198
p.P1184S	TCGA-BG-A222	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.6752
p.P447T	TCGA-D3-A8GB	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.7031
p.L33F	TCGA-D6-6516	HNSC	TCGA	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.6981
p.L33F	DO15623	HNSC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.6981
p.Q846K	TCGA-E6-A1LX	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation rewiring degron network	0.3056
p.Q846K	TCGA-E6-A1LX	UCEC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation rewiring degron network	0.0833
p.P1184L	TCGA-EE-A2A2	SKCM	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.7582
p.S385Y	TCGA-EO-A3AV	UCEC	TCGA	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.712
p.F1094V	TCGA-EO-A3B0	UCEC	TCGA	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.2778
p.D853N	TCGA-EY-A215	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.6932
p.N25S	TCGA-F2-A7TX	PAAD	TCGA	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.2222
p.N25S	DO50254	PAAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.2222
p.P278L	TCGA-L5-A43M	ESCA	TCGA	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1389
p.Q291E	TCGA-Q9-A6FU	ESCA	TCGA	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2778
p.H928R	TCGA-UF-A71E	HNSC	TCGA	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.25
p.P1103T	TCGA-UZ-A9PX	KIRP	TCGA	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.2778
p.S930F	TCGA-Z2-A8RT	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.3056
p.E873K	TCGA-ZJ-A8QR	CESC	TCGA	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation rewiring degron network	0.1944
p.S287T	DO224987	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.6005
p.E445K	DO2641	BRCA	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.591
p.T852I	DO5060	BRCA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.5966
p.I381V	DO51603	CESC	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.5965
p.E24K	DO6338	CESC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1944
p.V376A	DO9346	COAD	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1944
p.M871L	DO50092	COAD	ICGC	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation rewiring degron network	0.0833
p.M871L	DO50092	COAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation rewiring degron network	0.25
p.P28S	DO10276	COAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.3056
p.P931S	DO9812	COAD	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.6752
p.T1097N	DO8594	COAD	ICGC	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation altering degron motif	0.8166
p.Y39H	DO8264	COAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.2222
p.P867L	DO8312	COAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.6471
p.P867L	DO228542	GACA	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.6471
p.R1183W	DO222765	COCA	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.8634
p.P926L	DO233888	GACA	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.P926L	DO230506	PRAD	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.P926L	DO229456	SKCA	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.P926L	DO51273	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.P926L	DO42825	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.P23L	DO12946	GBM	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1667
p.E450K	DO219080	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2778
p.D449N	DO219080	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.3056
p.S38C	DO16269	KIRC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.25
p.T846N	DO228921	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation rewiring degron network	0.3056
p.T846N	DO228921	LICA	ICGC	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation rewiring degron network	0.0833
p.P853H	DO228948	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.6583
p.P853H	DO228950	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.6583
p.A873D	DO228948	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation rewiring degron network	0.1944
p.P851H	DO228950	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.7694
p.P865Q	DO228971	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.7035
p.T868K	DO228986	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.7306
p.T868K	DO229031	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.7306
p.P35T	DO229018	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.7031
p.H22N	DO229032	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1389
p.H22N	DO229036	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1389
p.D940E	DO229038	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.T930N	DO229037	LICA	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.3056
p.Q30K	DO229037	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.5833
p.I525V	DO52279	LIHC	ICGC	PGTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.H451R	DO26716	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.25
p.T390P	DO27779	MALY	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2778
p.T516M	DO51407	PRAD	ICGC	PGTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7423
p.I1189M	DO36556	READ	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation altering degron motif	0.6507
p.S382F	DO229459	SKCA	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.6871
p.P1087L	DO37583	SKCM	ICGC	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.0833
p.L19I	DO47491	SKCM	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.0556
p.P926S	DO37971	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.R924M	DO38567	STAD	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1389
p.P1197S	DO51761	STAD	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.1389
p.R508C	DO47769	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.K506E	DO42023	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	514:518	Mutation substituting flanking lysine	0.2222
p.S1094Y	DO42320	UCEC	ICGC	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.2778
p.S1094Y	DO43186	UCEC	ICGC	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.2778
p.L43I	DO41020	UCEC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1111
p.S288Y	DO52412	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.712
p.G291D	DO41752	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2778
p.T864I	DO52402	UCEC	ICGC	PTPTPT	DEG_SCF_FBW7_1	863:868	Mutation altering degron motif	0.7078
p.P1087S	DO42977	UCEC	ICGC	VTPFGS	DEG_SCF_FBW7_1	1096:1101	Mutation rewiring degron network	0.0833
p.T379A	DO41235	UCEC	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2778
p.E457D	DO41235	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0833
p.A437D	DO43755	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1389
p.A941T	DO42472	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.F929C	DO41133	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2778
p.P926Q	DO42665	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.G291S	SIDM01954	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2778
p.G434V	SIDM00672	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.V375M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1667
p.V375M	ACH-000636	Leukemia	CCLE	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1667
p.V375M	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ISLTPSNS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1667
p.T1194P	SIDM00845	Burkitt's Lymphoma	GDSC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2222
p.T1194P	ACH-000786	Lymphoma	CCLE	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2222
p.T1194P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2222
p.Q278P	SIDM00202	Ewing's Sarcoma	GDSC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1389
p.Q278P	EW-3	bone	COSMIC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1389
p.I848V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.5965
p.I848V	ACH-000563	Lung Cancer	CCLE	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.5965
p.I848V	EBC-1	lung	COSMIC	PIHTPTPT	DEG_SCF_FBW7_1	847:854	Mutation altering degron motif	0.5965
p.S436F	SIDM00767	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.S436F	ACH-001136	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.S436F	NCI-H187	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1111
p.N1200S	SIDM00294	Small Cell Lung Carcinoma	GDSC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.0556
p.N1200S	ACH-001549	Lung Cancer	CCLE	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.0556
p.N1200S	LU-135	lung	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.0556
p.D34N	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.5821
p.D34N	ACH-000878	Lung Cancer	CCLE	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.5821
p.D34N	HCC-15	lung	COSMIC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.5821
p.M286V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.6097
p.M286V	SW900	lung	COSMIC	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.6097
p.E922G	SIDM00217	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.E922G	ACH-000999	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.E922G	SNU-1040	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.P452R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.P452R	ACH-000637	Esophageal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.P452R	KYSE-520	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.P859L	SIDM01629	Melanoma	GDSC	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation altering degron motif	0.6471
p.P859L	ACH-000404	Skin Cancer	CCLE	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation altering degron motif	0.6471
p.P859S	SIDM01629	Melanoma	GDSC	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation altering degron motif	0.5641
p.P859S	ACH-000404	Skin Cancer	CCLE	PTPTPTPT	DEG_SCF_FBW7_1	855:862	Mutation altering degron motif	0.5641
p.T446K	ACH-000552	Colon/Colorectal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.7306
p.R275P	ACH-000659	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.0556
p.R275P	ACH-001386	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.0556
p.P38T	ACH-000971	Colon/Colorectal Cancer	CCLE	KQEVYDE	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.25
p.P1192T	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	1182:1190	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX7

UniProt ID: Q2KHR2

Entrez ID: 64864

Protein name: DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX7 in