DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SPOP_SBC_1

Location: 444:448

E3 ligase: SPOP

DEGRON score: 0.5922

ASA_SCORE: 92.78

COIL: 0.929

CONS_SCORE: 0.3173

DSS_SCORE: 0.6921

HELIX: 0.0518

FCONS_SCORE: 0.92

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P436R	TCGA-85-8354	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.1111
p.T448A	TCGA-AP-A1DK	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.7139
p.P447T	TCGA-D3-A8GB	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.7031
p.E445K	DO2641	BRCA	ICGC	PETSS	DEG_SPOP_SBC_1	0.591
p.E450K	DO219080	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.2778
p.D449N	DO219080	HNSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.3056
p.H451R	DO26716	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.25
p.E457D	DO41235	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.0833
p.A437D	DO43755	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.1389
p.G434V	SIDM00672	Hepatocellular Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.0556
p.S436F	SIDM00767	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.S436F	ACH-001136	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.1111
p.S436F	NCI-H187	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1111
p.P452R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.2222
p.P452R	ACH-000637	Esophageal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.2222
p.P452R	KYSE-520	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	0.2222
p.T446K	ACH-000552	Colon/Colorectal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with RFX7 mutations

All proteins holding degron of PETSS