DegronMD - Q5JXC2(MIIP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A79V	TCGA-2Y-A9GT	LIHC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.3056
p.A79V	DO219506	LIHC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.3056
p.P384L	TCGA-51-4079	LUSC	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.D78N	TCGA-AA-3864	COAD	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.D78N	DO8490	COAD	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.D78N	DO27961	ORCA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.R85C	TCGA-B5-A3FC	UCEC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.719
p.R85C	TCGA-DD-AAE7	LIHC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.719
p.R85C	DO52262	LIHC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.719
p.R85C	DO41871	UCEC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.719
p.P379S	TCGA-D3-A51N	SKCM	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1944
p.P379S	DO47274	SKCM	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1944
p.S94F	TCGA-D3-A51T	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1667
p.S94F	DO47389	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1667
p.S90L	TCGA-EE-A2MR	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.S90L	TCGA-GN-A266	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.S90L	DO37819	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.S90L	DO37432	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.P357S	TCGA-ER-A2NE	SKCM	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.P357S	DO48663	SKCM	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.R380Q	TCGA-F4-6854	COAD	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1667
p.R68W	TCGA-FI-A2D0	UCEC	TCGA	PSTPETS	DEG_SCF_FBW7_1	52:58	Mutation rewiring degron network	0.0556
p.R68W	TCGA-FI-A2D0	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.0833
p.R68W	DO43891	UCEC	ICGC	PSTPETS	DEG_SCF_FBW7_1	52:58	Mutation rewiring degron network	0.0556
p.R68W	DO43891	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.0833
p.P97L	TCGA-FS-A1ZA	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0833
p.P97L	DO37551	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0833
p.V383I	TCGA-HU-A4G8	STAD	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0833
p.V383I	DO47819	STAD	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0833
p.T57M	TCGA-L5-A88Z	ESCA	TCGA	PSTPETS	DEG_SCF_FBW7_1	52:58	Mutation altering degron motif	0.7423
p.T57M	TCGA-L5-A88Z	ESCA	TCGA	PETSS	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.8534
p.R85L	DO229027	LICA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.7316
p.A93S	DO229036	LICA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1944
p.A79T	DO45299	LIRI	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.3056
p.L95F	DO222908	MELA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1389
p.P371T	DO232826	NACA	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.7031
p.G69D	DO47159	RECA	ICGC	PETSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.0556
p.P381S	SIDM01090	Colorectal Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM01112	Osteosarcoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM00878	Breast Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM01173	Rhabdomyosarcoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM00785	Acute Myeloid Leukemia	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.P381S	SIDM01664	Prostate Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1389
p.C66S	SIDM00377	Other Sarcomas	GDSC	PSTPETS	DEG_SCF_FBW7_1	52:58	Mutation rewiring degron network	0.1111
p.C66S	SIDM00377	Other Sarcomas	GDSC	PETSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1389
p.P77S	SIDM00200	Ewing's Sarcoma	GDSC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.P77S	ACH-002112	Bone Cancer	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.P77S	EW-12	bone	COSMIC	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.25
p.H359Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1111
p.H359Y	ACH-002220	Lymphoma	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1111
p.H359Y	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1111
p.P371L	SIDM00982	Glioblastoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.7582
p.P371L	42-MG-BA	central nervous system	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.7582
p.P384T	SIDM00980	Gastric Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.P384T	ACH-000948	Gastric Cancer	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.P384T	23132-87	stomach	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0556
p.P369L	SIDM01728	Endometrial Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.6471
p.P369L	ACH-000173	Endometrial/Uterine Cancer	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.6471
p.R85H	ACH-001794	Liposarcoma	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.7133
p.R85H	ACH-001795	Liposarcoma	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIIP

UniProt ID: Q5JXC2

Entrez ID: 60672

Protein name: Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIIP in