DegronMD

Uniprot ID: Q5JXC2

Source protein: Migration and invasion-inhibitory protein

Source gene: MIIP

Class: DEG_APCC_DBOX_1

Location: 80:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6813

ASA_SCORE: 80.3444

COIL: 0.6389

CONS_SCORE: 0.3011

DSS_SCORE: 0.4865

HELIX: 0.2284

FCONS_SCORE: 1.0165

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A79V	TCGA-2Y-A9GT	LIHC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.3056
p.A79V	DO219506	LIHC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.3056
p.D78N	TCGA-AA-3864	COAD	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.D78N	DO8490	COAD	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.D78N	DO27961	ORCA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.R85C	TCGA-B5-A3FC	UCEC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.719
p.R85C	TCGA-DD-AAE7	LIHC	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.719
p.R85C	DO52262	LIHC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.719
p.R85C	DO41871	UCEC	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.719
p.S94F	TCGA-D3-A51T	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.1667
p.S94F	DO47389	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.1667
p.S90L	TCGA-EE-A2MR	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.S90L	TCGA-GN-A266	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.S90L	DO37819	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.S90L	DO37432	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.2778
p.P97L	TCGA-FS-A1ZA	SKCM	TCGA	CRGDLRDVA	DEG_APCC_DBOX_1	0.0833
p.P97L	DO37551	SKCM	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.0833
p.R85L	DO229027	LICA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.7316
p.A93S	DO229036	LICA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.1944
p.A79T	DO45299	LIRI	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.3056
p.L95F	DO222908	MELA	ICGC	CRGDLRDVA	DEG_APCC_DBOX_1	0.1389
p.P77S	SIDM00200	Ewing's Sarcoma	GDSC	CRGDLRDVA	DEG_APCC_DBOX_1	0.25
p.P77S	ACH-002112	Bone Cancer	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	0.25
p.P77S	EW-12	bone	COSMIC	CRGDLRDVA	DEG_APCC_DBOX_1	0.25
p.R85H	ACH-001794	Liposarcoma	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	0.7133
p.R85H	ACH-001795	Liposarcoma	CCLE	CRGDLRDVA	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JXC2	Migration and invasion-inhibitory protein	DEG_APCC_DBOX_1	80:88	CRGDLRDVA	APC,CDC20,FZR1	0.6813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons