DegronMD

Uniprot ID: Q5JXC2

Source protein: Migration and invasion-inhibitory protein

Source gene: MIIP

Class: DEG_SCF_FBW7_1

Location: 367:374

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 74.7375

COIL: 0.8991

CONS_SCORE: 0.462

DSS_SCORE: 0.6011

HELIX: 0.0155

FCONS_SCORE: 1.1526

RIG_SCORE: 0.6152

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P384L	TCGA-51-4079	LUSC	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.P379S	TCGA-D3-A51N	SKCM	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	0.1944
p.P379S	DO47274	SKCM	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	0.1944
p.P357S	TCGA-ER-A2NE	SKCM	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.P357S	DO48663	SKCM	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.R380Q	TCGA-F4-6854	COAD	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	0.1667
p.V383I	TCGA-HU-A4G8	STAD	TCGA	LPPTPTWS	DEG_SCF_FBW7_1	0.0833
p.V383I	DO47819	STAD	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	0.0833
p.P371T	DO232826	NACA	ICGC	LPPTPTWS	DEG_SCF_FBW7_1	0.7031
p.P381S	SIDM01090	Colorectal Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM01112	Osteosarcoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM00878	Breast Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM01173	Rhabdomyosarcoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM00785	Acute Myeloid Leukemia	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.P381S	SIDM01664	Prostate Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1389
p.H359Y	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.1111
p.H359Y	ACH-002220	Lymphoma	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	0.1111
p.H359Y	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	0.1111
p.P371L	SIDM00982	Glioblastoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.7582
p.P371L	42-MG-BA	central_nervous_system	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	0.7582
p.P384T	SIDM00980	Gastric Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.P384T	ACH-000948	Gastric Cancer	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.P384T	23132-87	stomach	COSMIC	LPPTPTWS	DEG_SCF_FBW7_1	0.0556
p.P369L	SIDM01728	Endometrial Carcinoma	GDSC	LPPTPTWS	DEG_SCF_FBW7_1	0.6471
p.P369L	ACH-000173	Endometrial/Uterine Cancer	CCLE	LPPTPTWS	DEG_SCF_FBW7_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPPTPTWS

Degron related mutations and impact score

Drug responses associated with MIIP mutations

All proteins holding degron of LPPTPTWS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SCF_FBW7_1	367:374	LPPTPTWS	FBXW7	0.9975	More...