DegronMD

Uniprot ID: Q8IZF0

Source protein: Sodium leak channel NALCN

Source gene: NALCN

Class: DEG_SPOP_SBC_1

Location: 1634:1638

E3 ligase: SPOP

DEGRON score: 0.7934

ASA_SCORE: 78.12

COIL: 0.8086

CONS_SCORE: 0.2621

DSS_SCORE: 0.8559

HELIX: 0.1672

FCONS_SCORE: 0.9221

RIG_SCORE: 0.6263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1648L	TCGA-AP-A056	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.0556
p.S1648L	DO43971	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.0556
p.L1643M	TCGA-AP-A059	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.1944
p.L1643M	DO41361	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.1944
p.P1634T	TCGA-AP-A059	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	0.7031
p.P1634T	DO41361	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	0.7031
p.T1646M	TCGA-BR-6453	STAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.1111
p.T1646M	DO38543	STAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.1111
p.P1634L	TCGA-ER-A193	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	0.7582
p.P1634L	DO47368	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	0.7582
p.L1643P	TCGA-L5-A8NK	ESCA	TCGA	PETSS	DEG_SPOP_SBC_1	0.1944
p.N1630K	DO234384	ESAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.2222
p.S1638N	DO233888	GACA	ICGC	PETSS	DEG_SPOP_SBC_1	0.7069
p.S1638N	SIDM00933	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.7069
p.S1638N	ACH-000856	Breast Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.7069
p.S1638N	CAL-51	breast	COSMIC	PETSS	DEG_SPOP_SBC_1	0.7069
p.S1631R	DO229038	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	0.25
p.T1646K	DO23328	LINC	ICGC	PETSS	DEG_SPOP_SBC_1	0.1111
p.Q1641K	DO46382	OV	ICGC	PETSS	DEG_SPOP_SBC_1	0.25
p.S1631N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.25
p.S1631N	ACH-000866	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.25
p.S1631N	NCI-H1048	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.25
p.T1646S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.T1646S	ACH-000916	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.1111
p.T1646S	NCI-H1573	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with NALCN mutations

All proteins holding degron of PETSS