DegronMD - Q96JG9(ZNF469)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G704D	TCGA-A5-A2K5	UCEC	TCGA	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1944
p.G704D	DO41379	UCEC	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1944
p.V3040M	TCGA-A6-6649	COAD	TCGA	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2778
p.S1384R	TCGA-AP-A059	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1381:1385	Mutation altering degron motif	0.7427
p.A2382V	TCGA-AX-A06H	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.5825
p.P2781L	TCGA-AX-A2HC	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation rewiring degron network	0.2778
p.P2781L	TCGA-AX-A2HC	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.3056
p.P2794S	TCGA-D1-A17H	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.1111
p.V2803F	TCGA-DD-AADA	LIHC	TCGA	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation rewiring degron network	0.1667
p.A2813T	TCGA-DD-AADO	LIHC	TCGA	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation altering degron motif	0.6028
p.A869V	TCGA-IG-A4QS	ESCA	TCGA	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation altering degron motif	0.5825
p.S607C	TCGA-KR-A7K0	LIHC	TCGA	PMSSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.S607C	DO49696	LIHC	ICGC	PMSSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.K2819M	TCGA-OR-A5KB	ACC	TCGA	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation substituting flanking lysine	0.3056
p.G704S	TCGA-SC-A6LN	MESO	TCGA	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1944
p.G704A	TCGA-SC-A6LN	MESO	TCGA	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1944
p.E1392K	TCGA-VS-A9UY	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	1381:1385	Mutation rewiring degron network	0.1389
p.T2794M	DO225167	BRCA	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.1111
p.P3305S	DO49009	CESC	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation substituting flanking lysine	0.3611
p.A3271V	DO49095	COAD	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.1667
p.P3040L	DO10140	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2778
p.R3042C	DO10244	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2222
p.R3042C	DO35442	PACA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2222
p.R3042C	DO46877	RECA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2222
p.A1444V	DO8842	COAD	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.25
p.E2792D	DO8898	COAD	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.1667
p.R3042H	DO8642	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2222
p.E3047G	DO8479	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.0833
p.E871K	DO230309	COCA	ICGC	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.3056
p.E871K	DO222434	MELA	ICGC	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.3056
p.G3173R	DO227549	COCA	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation rewiring degron network	0.1667
p.T3307K	DO227982	COCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation rewiring degron network	0.1944
p.R699Q	DO222853	COCA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.0556
p.P1448L	DO229010	COCA	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.P1448L	DO229013	COCA	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.P1448L	DO229016	COCA	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.P1448L	DO229003	COCA	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.P1448L	DO229005	COCA	ICGC	PPLY	ITCH	1438:1441	Mutation rewiring degron network	0.1389
p.G2386R	DO229016	COCA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.G2386R	DO229003	COCA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.G2386R	DO229005	COCA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.G2386R	DO234285	ESAD	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.G2386R	DO230993	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.G2386R	DO218908	SKCA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.7568
p.S2772N	DO50446	ESAD	ICGC	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation rewiring degron network	0.25
p.S2772N	DO50446	ESAD	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.0556
p.A3286V	DO234226	ESAD	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.2778
p.A3286V	DO234226	ESAD	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation rewiring degron network	0.0833
p.H3193Q	DO234170	ESAD	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation rewiring degron network	0.1667
p.T3044M	DO233163	GACA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.1667
p.T3044M	DO233887	GACA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.1667
p.P2380S	DO233271	GACA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.2778
p.G701R	DO11854	GBM	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1111
p.G2788D	DO11854	GBM	ICGC	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation rewiring degron network	0.0833
p.G2788D	DO11854	GBM	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.2778
p.D2777V	DO230659	LAML	ICGC	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation altering degron motif	0.7785
p.D2777V	DO231049	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation altering degron motif	0.7785
p.S863T	DO228207	LICA	ICGC	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.2778
p.W2790L	DO228974	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.2222
p.E2791D	DO228976	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	2782:2786	Mutation rewiring degron network	0.1944
p.G701W	DO229018	LICA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1111
p.G701W	DO229028	LICA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1111
p.G701W	DO229037	LICA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1111
p.G701W	DO229006	LICA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1111
p.R3274L	DO229032	LICA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.25
p.V867F	DO229037	LICA	ICGC	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation altering degron motif	0.7068
p.S3280I	DO229009	LICA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation altering degron motif	0.7341
p.M3189K	DO219509	LIHC	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation rewiring degron network	0.2778
p.G3030S	DO230940	LUSC	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.25
p.G3030S	DO224584	LUSC	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.25
p.A3176S	DO26553	LUSC	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation rewiring degron network	0.25
p.G3034E	DO220879	MELA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation altering degron motif	0.6087
p.P3493S	DO220891	MELA	ICGC	APSTT	DEG_SPOP_SBC_1	3488:3492	Mutation rewiring degron network	0.3056
p.D2379N	DO220907	MELA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.25
p.D2379N	DO222653	MELA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.25
p.S77F	DO222363	MELA	ICGC	APSST	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.S77F	ACH-000784	Esophageal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.P2380T	DO232832	NACA	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.2778
p.F717Y	DO233296	NACA	ICGC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.1944
p.C3028S	DO233383	RECA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.1944
p.A82V	DO233516	RECA	ICGC	APSST	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.5825
p.P3033S	DO229456	SKCA	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation altering degron motif	0.6752
p.S1381R	DO229462	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	1381:1385	Mutation altering degron motif	0.7427
p.P93L	DO37409	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.P2383L	DO38663	STAD	ICGC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.6471
p.G3300S	DO229208	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation altering degron motif	0.6993
p.P3480S	DO229211	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	3488:3492	Mutation rewiring degron network	0.1111
p.D3186N	DO229224	THCA	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation altering degron motif	0.6932
p.D3298N	DO229240	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation altering degron motif	0.6932
p.A3286S	DO229250	THCA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.2778
p.A3286S	DO229250	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation rewiring degron network	0.0833
p.G1386R	DO223286	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1381:1385	Mutation rewiring degron network	0.3056
p.P2809L	DO41572	UCEC	ICGC	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation altering degron motif	0.6471
p.P3040S	DO41572	UCEC	ICGC	LGPFED	LIG_APCC_ABBA_1	3033:3038	Mutation rewiring degron network	0.2778
p.P2822S	DO41847	UCEC	ICGC	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation rewiring degron network	0.1111
p.A3289D	SIDM02018	Colorectal Carcinoma	GDSC	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.1944
p.A3289D	SIDM02018	Colorectal Carcinoma	GDSC	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation rewiring degron network	0.1667
p.R699W	SIDM01314	Colorectal Carcinoma	GDSC	PPPY	ITCH	709:712	Mutation rewiring degron network	0.0556
p.D2393E	SIDM01271	Esophageal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.1389
p.E1438Q	SIDM00025	Head and Neck Carcinoma	GDSC	PPLY	ITCH	1438:1441	Mutation altering degron motif	0.6744
p.A2382G	ACH-000274	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.754
p.A2382G	ACH-000517	Pancreatic Cancer	CCLE	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation altering degron motif	0.754
p.N3191Y	ACH-000393	Liver Cancer	CCLE	ARRSLGDLP	DEG_APCC_DBOX_1	3179:3187	Mutation rewiring degron network	0.2222
p.K89R	ACH-000693	Esophageal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.3611
p.P3478S	ACH-000788	Skin Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	3488:3492	Mutation rewiring degron network	0.0556
p.S2816F	ACH-000799	Skin Cancer	CCLE	PTPDAS	DEG_SCF_FBW7_1	2809:2814	Mutation rewiring degron network	0.2778
p.D1378V	ACH-000819	Brain Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1381:1385	Mutation rewiring degron network	0.25
p.G3275A	ACH-000856	Breast Cancer	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.2778
p.P2768R	ACH-000957	Colon/Colorectal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	2775:2779	Mutation rewiring degron network	0.1389
p.H3301Y	ACH-000966	Ovarian Cancer	CCLE	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation altering degron motif	0.6118
p.A3303V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LQATPVHE	DEG_SCF_FBW7_2	3295:3302	Mutation rewiring degron network	0.3056
p.E3488K	ACH-001403	Ovarian Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	3488:3492	Mutation altering degron motif	0.7022
p.R2387H	ACH-001484	Leukemia	CCLE	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.3056
p.R2387H	ACH-001485	Leukemia	CCLE	APSST	DEG_SPOP_SBC_1	2382:2386	Mutation rewiring degron network	0.3056
p.S3280R	ACH-001484	Leukemia	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation altering degron motif	0.7427
p.S3280R	ACH-001485	Leukemia	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation altering degron motif	0.7427
p.R3274G	ACH-001652	Endometrial/Uterine Cancer	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	3277:3284	Mutation rewiring degron network	0.25
p.G878D	ACH-001834	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.1111
p.G878D	ACH-001835	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.1111
p.G878D	ACH-001836	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	865:870	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF469

UniProt ID: Q96JG9

Entrez ID:

Protein name: Zinc finger protein 469

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF469 in