DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: DEG_SCF_FBW7_1

Location: 3277:3284

E3 ligase: FBXW7

DEGRON score: 0.9477

ASA_SCORE: 92.55

COIL: 0.9369

CONS_SCORE: 0.4887

DSS_SCORE: 0.8202

HELIX: 0.0173

FCONS_SCORE: 1.0925

RIG_SCORE: 0.5045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3271V	DO49095	COAD	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	0.1667
p.A3286V	DO234226	ESAD	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	0.2778
p.R3274L	DO229032	LICA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	0.25
p.S3280I	DO229009	LICA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	0.7341
p.A3286S	DO229250	THCA	ICGC	PRTTPSPS	DEG_SCF_FBW7_1	0.2778
p.A3289D	SIDM02018	Colorectal Carcinoma	GDSC	PRTTPSPS	DEG_SCF_FBW7_1	0.1944
p.G3275A	ACH-000856	Breast Cancer	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	0.2778
p.S3280R	ACH-001484	Leukemia	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	0.7427
p.S3280R	ACH-001485	Leukemia	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	0.7427
p.R3274G	ACH-001652	Endometrial/Uterine Cancer	CCLE	PRTTPSPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	DEG_SCF_FBW7_1	3277:3284	PRTTPSPS	FBXW7	0.9477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons