DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: LIG_APCC_ABBA_1

Location: 865:870

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8498

ASA_SCORE: 64.8833

COIL: 0.5982

CONS_SCORE: 0.8927

DSS_SCORE: 0.6439

HELIX: 0.3327

FCONS_SCORE: 1.0179

RIG_SCORE: 0.7733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A869V	TCGA-IG-A4QS	ESCA	TCGA	IDVFAD	LIG_APCC_ABBA_1	0.5825
p.E871K	DO230309	COCA	ICGC	IDVFAD	LIG_APCC_ABBA_1	0.3056
p.E871K	DO222434	MELA	ICGC	IDVFAD	LIG_APCC_ABBA_1	0.3056
p.S863T	DO228207	LICA	ICGC	IDVFAD	LIG_APCC_ABBA_1	0.2778
p.V867F	DO229037	LICA	ICGC	IDVFAD	LIG_APCC_ABBA_1	0.7068
p.G878D	ACH-001834	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	0.1111
p.G878D	ACH-001835	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	0.1111
p.G878D	ACH-001836	Bile Duct Cancer	CCLE	IDVFAD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	LIG_APCC_ABBA_1	865:870	IDVFAD	APC,CDC20,FZR1	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons