DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: DEG_APCC_DBOX_1

Location: 3179:3187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8121

ASA_SCORE: 86.3667

COIL: 0.7557

CONS_SCORE: 0.8738

DSS_SCORE: 0.4087

HELIX: 0.1849

FCONS_SCORE: 1.1734

RIG_SCORE: 0.6761

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3186N	DO229224	THCA	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	0.6932
p.M3189K	DO219509	LIHC	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	0.2778
p.A3176S	DO26553	LUSC	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	0.25
p.N3191Y	ACH-000393	Liver Cancer	CCLE	ARRSLGDLP	DEG_APCC_DBOX_1	0.2222
p.G3173R	DO227549	COCA	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	0.1667
p.H3193Q	DO234170	ESAD	ICGC	ARRSLGDLP	DEG_APCC_DBOX_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	DEG_APCC_DBOX_1	3179:3187	ARRSLGDLP	APC,CDC20,FZR1	0.8121	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons