DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PMSSS
Uniprot ID:
Q96JG9
Source protein:
Zinc finger protein 469
Source gene:
ZNF469
Class:
DEG_SPOP_SBC_1
Location:
610:614
E3 ligase:
SPOP
DEGRON score:
0.8719
ASA_SCORE:
89.98
COIL:
0.9648
CONS_SCORE:
0.8712
DSS_SCORE:
0.6834
HELIX:
0.013
FCONS_SCORE:
1.0478
RIG_SCORE:
0.521
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S607C
TCGA-KR-A7K0
LIHC
TCGA
PMSSS
DEG_SPOP_SBC_1
0.25
p.S607C
DO49696
LIHC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.25
Drug responses associated with ZNF469 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PMSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15062
Zinc finger and BTB domain-containing protein 5
DEG_SPOP_SBC_1
170:174
PMSSS
SPOP
0.8158
More...
P01266
Thyroglobulin
DEG_SPOP_SBC_1
2443:2447
PMSSS
SPOP
0.5138
More...
P39880
Homeobox protein cut-like 1
DEG_SPOP_SBC_1
1060:1064
PMSSS
SPOP
0.9994
More...
Q2KHR2
DNA-binding protein RFX7
DEG_SPOP_SBC_1
285:289
PMSSS
SPOP
0.9583
More...
Q6AWC2
Protein WWC2
DEG_SPOP_SBC_1
569:573
PMSSS
SPOP
0.827
More...
Q6PCT2
F-box/LRR-repeat protein 19
DEG_SPOP_SBC_1
20:24
PMSSS
SPOP
0.8896
More...
Q96JG9
Zinc finger protein 469
DEG_SPOP_SBC_1
610:614
PMSSS
SPOP
0.8719
More...
Q9H0N0
Ras-related protein Rab-6C
DEG_SPOP_SBC_1
211:215
PMSSS
SPOP
0.9712
More...
Q9H4Z2
Zinc finger protein 335
DEG_SPOP_SBC_1
180:184
PMSSS
SPOP
0.5585
More...
Q9ULL8
Protein Shroom4
DEG_SPOP_SBC_1
813:817
PMSSS
SPOP
0.7425
More...
Q9ULT8
E3 ubiquitin-protein ligase HECTD1
DEG_SPOP_SBC_1
1527:1531
PMSSS
SPOP
0.9987
More...
Q9NW07
Zinc finger protein 358
DEG_SPOP_SBC_1
87:91
PMSSS
SPOP
0.9771
More...