DegronMD - Q6AWC2(WWC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A539D	TCGA-05-4426	LUAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0833
p.E918D	TCGA-2W-A8YY	CESC	TCGA	TEDLSSCTSVPEM	DEG_COP1_1	923:935	Mutation rewiring degron network	0.1944
p.S457T	TCGA-37-3783	LUSC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.6005
p.S448L	TCGA-56-8629	LUSC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0833
p.H579R	TCGA-66-2758	LUSC	TCGA	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1667
p.E468K	TCGA-AR-A1AJ	BRCA	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.25
p.S473N	TCGA-B5-A1MR	UCEC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1111
p.L546V	TCGA-DD-A73C	LIHC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.2778
p.R458I	TCGA-DF-A2KU	UCEC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.8102
p.S463F	TCGA-EE-A2GD	SKCM	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.6871
p.L578F	TCGA-EO-A22U	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.1944
p.S577F	TCGA-EY-A215	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.2222
p.Y470H	TCGA-G9-6363	PRAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation blocking phosphorylation signal	0.6389
p.N462S	TCGA-HU-A4G2	STAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.5958
p.S475R	TCGA-HU-A4GT	STAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.S551P	TCGA-JW-A5VL	CESC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.5641
p.S548L	TCGA-QS-A5YR	UCEC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.6556
p.T567M	TCGA-VQ-A8P2	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.2778
p.P558A	TCGA-XF-A8HF	BLCA	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.2778
p.A455S	DO228483	BRCA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2778
p.A455S	DO229010	COCA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2778
p.A455S	DO234285	ESAD	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2778
p.A455S	DO229489	LAML	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2778
p.E554Q	DO11669	GBM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.6744
p.R467G	DO228936	LICA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2778
p.E549D	DO229019	LICA	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.6758
p.A541V	DO229054	LICA	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation substituting flanking lysine	0.25
p.D469G	DO26963	LUSC	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.2222
p.R913W	DO43154	UCEC	ICGC	TEDLSSCTSVPEM	DEG_COP1_1	923:935	Mutation rewiring degron network	0.0556
p.P570T	DO42673	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation altering degron motif	0.7031
p.A447V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.A447V	ACH-000960	Leukemia	CCLE	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.A447V	REH	haematopoietic and lymphoid tissue	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.N945S	SIDM00929	Chondrosarcoma	GDSC	TEDLSSCTSVPEM	DEG_COP1_1	923:935	Mutation rewiring degron network	0.0556
p.G566C	SIDM00220	Ovarian Carcinoma	GDSC	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.G566C	SIDM00220	Ovarian Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.25
p.G566C	ACH-000962	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.G566C	ACH-000962	Ovarian Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.25
p.G566C	ACH-001145	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.G566C	ACH-001145	Ovarian Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.25
p.G566C	OC-314	ovary	COSMIC	SRSSLSSLS	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.G566C	OC-314	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	569:573	Mutation rewiring degron network	0.25
p.R450Q	SIDM01665	Colorectal Carcinoma	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1389
p.R450W	SIDM01387	Small Cell Lung Carcinoma	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1389
p.S475N	ACH-001970	Metastasis	CCLE	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.I599V	SNU-1040	large intestine	COSMIC	DSGGAS	DEG_SCF_TRCP1_1	609:614	Mutation rewiring degron network	0.0556
p.V454I	K5	thyroid	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.25
p.L447S	CAL-148	breast	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WWC2

UniProt ID: Q6AWC2

Entrez ID: 80014

Protein name: Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WWC2 in