DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TEDLSSCTSVPEM
Uniprot ID:
Q6AWC2
Source protein:
Protein WWC2
Source gene:
WWC2
Class:
DEG_COP1_1
Location:
923:935
E3 ligase:
COP1
DEGRON score:
0.5398
ASA_SCORE:
81.2538
COIL:
0.7761
CONS_SCORE:
0.2662
DSS_SCORE:
0.5571
HELIX:
0.1796
FCONS_SCORE:
0.9344
RIG_SCORE:
0.6837
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E918D
TCGA-2W-A8YY
CESC
TCGA
TEDLSSCTSVPEM
DEG_COP1_1
0.1944
p.R913W
DO43154
UCEC
ICGC
TEDLSSCTSVPEM
DEG_COP1_1
0.0556
p.N945S
SIDM00929
Chondrosarcoma
GDSC
TEDLSSCTSVPEM
DEG_COP1_1
0.0556
Drug responses associated with WWC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TEDLSSCTSVPEM
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6AWC2
Protein WWC2
DEG_COP1_1
923:935
TEDLSSCTSVPEM
COP1
0.5398
More...