DegronMD

Uniprot ID: Q6AWC2

Source protein: Protein WWC2

Source gene: WWC2

Class: DEG_APCC_DBOX_1

Location: 548:556

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.883

ASA_SCORE: 84.4444

COIL: 0.851

CONS_SCORE: 0.4388

DSS_SCORE: 0.4853

HELIX: 0.1236

FCONS_SCORE: 1.1479

RIG_SCORE: 0.5793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A539D	TCGA-05-4426	LUAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.0833
p.L546V	TCGA-DD-A73C	LIHC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.2778
p.S551P	TCGA-JW-A5VL	CESC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.5641
p.S548L	TCGA-QS-A5YR	UCEC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.6556
p.P558A	TCGA-XF-A8HF	BLCA	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.2778
p.E554Q	DO11669	GBM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.6744
p.E549D	DO229019	LICA	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.6758
p.A541V	DO229054	LICA	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.25
p.G566C	SIDM00220	Ovarian Carcinoma	GDSC	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556
p.G566C	ACH-000962	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556
p.G566C	ACH-001145	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556
p.G566C	OC-314	ovary	COSMIC	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons