DegronMD - Q9ULE0(WWC3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D444Y	TCGA-06-5416	GBM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.0556
p.D444Y	DO10880	GBM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.0556
p.S382R	TCGA-17-Z014	LUAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6316
p.H723L	TCGA-43-3394	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2222
p.H723L	DO26596	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2222
p.S724F	TCGA-44-3918	LUAD	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.25
p.S724F	DO23732	LUAD	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.25
p.H723D	TCGA-60-2714	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2222
p.H723D	DO26530	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2222
p.S385F	TCGA-73-7498	LUAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6871
p.S385F	TCGA-98-7454	LUSC	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6871
p.S385F	DO23802	LUAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6871
p.S385F	DO26460	LUSC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6871
p.T445M	TCGA-AA-3861	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation blocking phosphorylation signal	0.5278
p.T445M	TCGA-AA-3864	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation blocking phosphorylation signal	0.5278
p.T445M	DO8490	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation blocking phosphorylation signal	0.5278
p.T445M	DO9562	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation blocking phosphorylation signal	0.5278
p.T445M	ACH-001719	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation blocking phosphorylation signal	0.5278
p.A1025D	TCGA-AH-6643	READ	TCGA	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.0556
p.A1025D	DO36591	READ	ICGC	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.0556
p.R455H	TCGA-B5-A11I	UCEC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation altering degron motif	0.8244
p.R455H	DO41229	UCEC	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation altering degron motif	0.8244
p.E738D	TCGA-B5-A11J	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1389
p.E738D	DO43698	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1389
p.R721C	TCGA-BK-A6W3	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721C	DO50076	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721C	SIDM02013	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R1027W	TCGA-BR-4280	STAD	TCGA	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.1111
p.R1027W	DO38663	STAD	ICGC	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.1111
p.T651M	TCGA-BR-A4QL	STAD	TCGA	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.6312
p.T651M	DO38723	STAD	ICGC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.6312
p.R737W	TCGA-BS-A0UF	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R737W	TCGA-F1-6874	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R737W	DO38201	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R737W	DO41488	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R376S	TCGA-CK-5913	COAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1667
p.R376S	DO8826	COAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1667
p.S387N	TCGA-DD-A1EE	LIHC	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.5958
p.S387N	DO22857	LIHC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.5958
p.Y1036C	TCGA-DM-A1HB	COAD	TCGA	DYR	CBL_MET	1035:1037	Mutation altering degron motif	0.7087
p.R455C	TCGA-EE-A29A	SKCM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation altering degron motif	0.8301
p.R455C	DO37416	SKCM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation altering degron motif	0.8301
p.S388L	TCGA-EE-A29G	SKCM	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6556
p.S388L	DO47303	SKCM	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.6556
p.K1044N	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	1035:1037	Mutation substituting flanking lysine	0.25
p.K1044N	DO42713	UCEC	ICGC	DYR	CBL_MET	1035:1037	Mutation substituting flanking lysine	0.25
p.A739V	TCGA-EO-A22U	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1111
p.A739V	DO43755	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1111
p.A659T	TCGA-EO-A3AY	UCEC	TCGA	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation rewiring degron network	0.1944
p.A659T	DO43202	UCEC	ICGC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation rewiring degron network	0.1944
p.A659T	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation rewiring degron network	0.1944
p.I640V	TCGA-G3-A3CK	LIHC	TCGA	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation rewiring degron network	0.1111
p.I640V	DO22839	LIHC	ICGC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation rewiring degron network	0.1111
p.S466L	TCGA-G4-6586	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.2222
p.S466L	DO9698	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.2222
p.S375I	TCGA-G4-6588	COAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1389
p.S375I	DO10140	COAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1389
p.R376H	TCGA-GL-A9DC	KIRP	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1667
p.R376H	DO51556	KIRP	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1667
p.S448F	TCGA-GN-A4U3	SKCM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.1667
p.S448F	DO219484	SKCM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.1667
p.W722C	TCGA-IC-A6RE	ESCA	TCGA	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1944
p.C741G	DO48436	BLCA	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.0556
p.G650C	DO229019	LICA	ICGC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.76
p.S374Y	DO23134	LINC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.1111
p.R721P	DO35376	PACA	ICGC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.A1041V	DO229253	THCA	ICGC	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.2222
p.S382N	DO229257	THCA	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.5958
p.A1042V	SIDM02026	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1035:1037	Mutation rewiring degron network	0.1944
p.S451L	SIDM00392	Melanoma	GDSC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.25
p.S451L	ACH-000810	Skin Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.25
p.S451L	SK-MEL-30	skin	COSMIC	SRSSLSSLS	DEG_APCC_DBOX_1	454:462	Mutation rewiring degron network	0.25
p.R721H	SIDM00781	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721H	SIDM01210	Glioblastoma	GDSC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721H	SIDM01612	Endometrial Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721H	SIDM00780	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721H	SNU-C2B	large intestine	COSMIC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R721H	KNS-81-FD	central nervous system	COSMIC	VFTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.R383Q	SIDM00889	Cervical Carcinoma	GDSC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.7329
p.R383Q	C-33-A	cervix	COSMIC	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation altering degron motif	0.7329
p.D648G	SIDM00596	Endometrial Carcinoma	GDSC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.7198
p.D648G	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.7198
p.D648G	HEC-1	endometrium	COSMIC	DSGTPNT	DEG_SCF_TRCP1_1	648:654	Mutation altering degron motif	0.7198
p.A373S	ACH-001536	Bile Duct Cancer	CCLE	SRGSLSSVS	DEG_APCC_DBOX_1	382:390	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WWC3

UniProt ID: Q9ULE0

Entrez ID: 55841

Protein name: Protein WWC3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WWC3 in