DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGTPNT
Uniprot ID:
Q9ULE0
Source protein:
Protein WWC3
Source gene:
WWC3
Class:
DEG_SCF_TRCP1_1
Location:
648:654
E3 ligase:
BTRC
DEGRON score:
0.8555
ASA_SCORE:
76.1714
COIL:
0.8781
CONS_SCORE:
0.3007
DSS_SCORE:
0.1376
HELIX:
0.0216
FCONS_SCORE:
0.7822
RIG_SCORE:
0.7251
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T651M
TCGA-BR-A4QL
STAD
TCGA
DSGTPNT
DEG_SCF_TRCP1_1
0.6312
p.T651M
DO38723
STAD
ICGC
DSGTPNT
DEG_SCF_TRCP1_1
0.6312
p.A659T
TCGA-EO-A3AY
UCEC
TCGA
DSGTPNT
DEG_SCF_TRCP1_1
0.1944
p.A659T
DO43202
UCEC
ICGC
DSGTPNT
DEG_SCF_TRCP1_1
0.1944
p.A659T
SIDM00990
Non-Small Cell Lung Carcinoma
GDSC
DSGTPNT
DEG_SCF_TRCP1_1
0.1944
p.I640V
TCGA-G3-A3CK
LIHC
TCGA
DSGTPNT
DEG_SCF_TRCP1_1
0.1111
p.I640V
DO22839
LIHC
ICGC
DSGTPNT
DEG_SCF_TRCP1_1
0.1111
p.G650C
DO229019
LICA
ICGC
DSGTPNT
DEG_SCF_TRCP1_1
0.76
p.D648G
SIDM00596
Endometrial Carcinoma
GDSC
DSGTPNT
DEG_SCF_TRCP1_1
0.7198
p.D648G
ACH-001517
Endometrial/Uterine Cancer
CCLE
DSGTPNT
DEG_SCF_TRCP1_1
0.7198
p.D648G
HEC-1
endometrium
COSMIC
DSGTPNT
DEG_SCF_TRCP1_1
0.7198
Drug responses associated with WWC3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGTPNT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULE0
Protein WWC3
DEG_SCF_TRCP1_1
648:654
DSGTPNT
BTRC
0.8555
More...