DegronMD

Uniprot ID: Q9ULE0

Source protein: Protein WWC3

Source gene: WWC3

Class: DEG_APCC_DBOX_1

Location: 382:390

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9218

ASA_SCORE: 71.2889

COIL: 0.8066

CONS_SCORE: 0.5654

DSS_SCORE: 0.2729

HELIX: 0.1106

FCONS_SCORE: 1.2174

RIG_SCORE: 0.6363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S382R	TCGA-17-Z014	LUAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.6316
p.S385F	TCGA-73-7498	LUAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.6871
p.S385F	TCGA-98-7454	LUSC	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.6871
p.S385F	DO23802	LUAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.6871
p.S385F	DO26460	LUSC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.6871
p.R376S	TCGA-CK-5913	COAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.1667
p.R376S	DO8826	COAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.1667
p.S387N	TCGA-DD-A1EE	LIHC	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.5958
p.S387N	DO22857	LIHC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.5958
p.S388L	TCGA-EE-A29G	SKCM	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.6556
p.S388L	DO47303	SKCM	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.6556
p.S375I	TCGA-G4-6588	COAD	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.1389
p.S375I	DO10140	COAD	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.1389
p.R376H	TCGA-GL-A9DC	KIRP	TCGA	SRGSLSSVS	DEG_APCC_DBOX_1	0.1667
p.R376H	DO51556	KIRP	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.1667
p.S374Y	DO23134	LINC	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.1111
p.S382N	DO229257	THCA	ICGC	SRGSLSSVS	DEG_APCC_DBOX_1	0.5958
p.R383Q	SIDM00889	Cervical Carcinoma	GDSC	SRGSLSSVS	DEG_APCC_DBOX_1	0.7329
p.R383Q	C-33-A	cervix	COSMIC	SRGSLSSVS	DEG_APCC_DBOX_1	0.7329
p.A373S	ACH-001536	Bile Duct Cancer	CCLE	SRGSLSSVS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULE0	Protein WWC3	DEG_APCC_DBOX_1	382:390	SRGSLSSVS	APC,CDC20,FZR1	0.9218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons