DegronMD

Uniprot ID: Q9ULE0

Source protein: Protein WWC3

Source gene: WWC3

Class: DEG_SPOP_SBC_1

Location: 727:731

E3 ligase: SPOP

DEGRON score: 0.9576

ASA_SCORE: 68.04

COIL: 0.6738

CONS_SCORE: 0.2884

DSS_SCORE: 0.4334

HELIX: 0.0232

FCONS_SCORE: 0.7702

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H723L	TCGA-43-3394	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.2222
p.H723L	DO26596	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.S724F	TCGA-44-3918	LUAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.25
p.S724F	DO23732	LUAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.25
p.H723D	TCGA-60-2714	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.2222
p.H723D	DO26530	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.E738D	TCGA-B5-A11J	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1389
p.E738D	DO43698	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1389
p.R721C	TCGA-BK-A6W3	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721C	DO50076	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721C	SIDM02013	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R737W	TCGA-BS-A0UF	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R737W	TCGA-F1-6874	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R737W	DO38201	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R737W	DO41488	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.A739V	TCGA-EO-A22U	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1111
p.A739V	DO43755	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.W722C	TCGA-IC-A6RE	ESCA	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1944
p.C741G	DO48436	BLCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.R721P	DO35376	PACA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	SIDM00781	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	SIDM01210	Glioblastoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	SIDM01612	Endometrial Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	SIDM00780	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	SNU-C2B	large_intestine	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R721H	KNS-81-FD	central_nervous_system	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08779	Keratin, type I cytoskeletal 16	DEG_SPOP_SBC_1	443:447	VFTSS	SPOP	0.9648	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	465:469	VFTSS	SPOP	0.8674	More...
Q9ULE0	Protein WWC3	DEG_SPOP_SBC_1	727:731	VFTSS	SPOP	0.9576	More...
A5PL33	Protein KRBA1	DEG_SPOP_SBC_1	573:577	VFTSS	SPOP	0.85	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons