DegronMD - P08779(KRT16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R453C	TCGA-22-5479	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.R453C	TCGA-DX-A3LS	SARC	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.R453C	DO27287	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.R453C	DO219965	SARC	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.S451L	TCGA-AA-3977	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation blocking phosphorylation signal	0.6667
p.S451L	DO8730	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation blocking phosphorylation signal	0.6667
p.S437F	TCGA-AX-A1CE	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.S437F	DO42280	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.P457H	TCGA-B7-A5TI	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.P457H	DO222328	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.E442D	TCGA-D3-A2JP	SKCM	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.E442D	DO47407	SKCM	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.S450P	TCGA-EO-A3KX	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation blocking phosphorylation signal	0.6944
p.S450P	DO219774	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation blocking phosphorylation signal	0.6944
p.E442K	DO220851	MELA	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.R441C	DO27919	ORCA	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.R441C	SIDM00223	Small Cell Lung Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.R441C	ACH-002144	Lung Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.R441C	IST-SL1	lung	COSMIC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.G435D	DO229211	THCA	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1111
p.G435D	DO41199	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1111
p.S448L	SIDM01138	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.S448L	PANC-03-27	pancreas	COSMIC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.S448W	SIDM01318	Hepatocellular Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.S448W	ACH-001318	Liver Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.Q436L	SIDM01448	Head and Neck Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.Q436L	ACH-000500	Head and Neck Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.T445P	ACH-000989	Colon/Colorectal Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7031
p.S451W	D-283MED	central nervous system	COSMIC	VFTSS	DEG_SPOP_SBC_1	443:447	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for KRT16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT16

UniProt ID: P08779

Entrez ID: 3868

Protein name: Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT16 in