DegronMD

Uniprot ID: P08779

Source protein: Keratin, type I cytoskeletal 16

Source gene: KRT16

Class: DEG_SPOP_SBC_1

Location: 443:447

E3 ligase: SPOP

DEGRON score: 0.9648

ASA_SCORE: 84.66

COIL: 0.6714

CONS_SCORE: 0.3436

DSS_SCORE: 0.5612

HELIX: 0.0256

FCONS_SCORE: 0.7706

RIG_SCORE: 0.6388

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R453C	TCGA-22-5479	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R453C	TCGA-DX-A3LS	SARC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R453C	DO27287	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.R453C	DO219965	SARC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.S451L	TCGA-AA-3977	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.6667
p.S451L	DO8730	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.6667
p.S437F	TCGA-AX-A1CE	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.S437F	DO42280	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.P457H	TCGA-B7-A5TI	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.0556
p.P457H	DO222328	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.E442D	TCGA-D3-A2JP	SKCM	TCGA	VFTSS	DEG_SPOP_SBC_1	0.3056
p.E442D	DO47407	SKCM	ICGC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.S450P	TCGA-EO-A3KX	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.6944
p.S450P	DO219774	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.6944
p.E442K	DO220851	MELA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.R441C	DO27919	ORCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.2778
p.R441C	SIDM00223	Small Cell Lung Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2778
p.R441C	ACH-002144	Lung Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.2778
p.R441C	IST-SL1	lung	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.2778
p.G435D	DO229211	THCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.G435D	DO41199	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.S448L	SIDM01138	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.S448L	PANC-03-27	pancreas	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.S448W	SIDM01318	Hepatocellular Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.S448W	ACH-001318	Liver Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.3056
p.Q436L	SIDM01448	Head and Neck Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1389
p.Q436L	ACH-000500	Head and Neck Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.1389
p.T445P	ACH-000989	Colon/Colorectal Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.7031
p.S451W	D-283MED	central_nervous_system	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08779	Keratin, type I cytoskeletal 16	DEG_SPOP_SBC_1	443:447	VFTSS	SPOP	0.9648	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	465:469	VFTSS	SPOP	0.8674	More...
Q9ULE0	Protein WWC3	DEG_SPOP_SBC_1	727:731	VFTSS	SPOP	0.9576	More...
A5PL33	Protein KRBA1	DEG_SPOP_SBC_1	573:577	VFTSS	SPOP	0.85	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFTSS

Degron related mutations and impact score

Drug responses associated with KRT16 mutations

All proteins holding degron of VFTSS