DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: DEG_SPOP_SBC_1

Location: 465:469

E3 ligase: SPOP

DEGRON score: 0.8674

ASA_SCORE: 80.04

COIL: 0.7472

CONS_SCORE: 0.2942

DSS_SCORE: 0.5197

HELIX: 0.2258

FCONS_SCORE: 0.8701

RIG_SCORE: 0.7413

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R478C	TCGA-3A-A9I9	PAAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.0833
p.R478C	DO51679	PAAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0833
p.R478C	SIDM02019	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.0833
p.V465I	TCGA-5M-AAT6	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.7076
p.V465I	DO223703	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.7076
p.R478H	TCGA-AZ-6601	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.0833
p.R478H	TCGA-BR-8591	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.0833
p.R478H	DO8119	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0833
p.R478H	DO47973	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0833
p.S457L	TCGA-B5-A11E	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1111
p.S457L	DO233859	GACA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.S457L	DO41644	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.S476L	TCGA-B5-A1MR	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.5833
p.S476L	DO229446	SKCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.5833
p.S476L	DO41758	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.5833
p.D459N	TCGA-CA-6718	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.D459N	TCGA-CG-5728	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1667
p.D459N	DO7801	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.D459N	DO38619	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.K463R	TCGA-F4-6806	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.2778
p.K463R	DO8296	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.2778
p.N458K	TCGA-UY-A78O	BLCA	TCGA	VFTSS	DEG_SPOP_SBC_1	0.1389
p.N458K	DO219035	BLCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1389
p.S468N	DO234462	ESAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.7069
p.S468N	DO231031	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.7069
p.N479T	DO233930	GACA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.P477L	DO45211	LIRI	ICGC	VFTSS	DEG_SPOP_SBC_1	0.1111
p.P461T	SIDM00561	Other Blood Cancers	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.P461T	SIDM00566	Oral Cavity Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.P461T	SIDM01660	Kidney Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.P461T	SIDM01320	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.P461T	SIDM01391	Neuroblastoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.T456I	ACH-000941	Endometrial/Uterine Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08779	Keratin, type I cytoskeletal 16	DEG_SPOP_SBC_1	443:447	VFTSS	SPOP	0.9648	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	465:469	VFTSS	SPOP	0.8674	More...
Q9ULE0	Protein WWC3	DEG_SPOP_SBC_1	727:731	VFTSS	SPOP	0.9576	More...
A5PL33	Protein KRBA1	DEG_SPOP_SBC_1	573:577	VFTSS	SPOP	0.85	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFTSS

Degron related mutations and impact score

Drug responses associated with ARHGAP31 mutations

All proteins holding degron of VFTSS