DegronMD

Uniprot ID: A5PL33

Source protein: Protein KRBA1

Source gene: KRBA1

Class: DEG_SPOP_SBC_1

Location: 573:577

E3 ligase: SPOP

DEGRON score: 0.85

ASA_SCORE: 88.48

COIL: 0.9316

CONS_SCORE: 0.4557

DSS_SCORE: 0.2809

HELIX: 0.0422

FCONS_SCORE: 0.7055

RIG_SCORE: 0.7518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S576T	TCGA-34-8454	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	0.6005
p.S576T	DO50094	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	0.6005
p.V578I	TCGA-HU-A4GX	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	0.3056
p.V578I	DO222905	BTCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.V578I	DO47757	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	0.3056
p.R563Q	DO222432	ESCA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.S569I	DO229026	LICA	ICGC	VFTSS	DEG_SPOP_SBC_1	0.2222
p.R587H	SIDM00778	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.R587H	SIDM01774	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.P563L	SIDM01045	Endometrial Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.P563L	EN	endometrium	COSMIC	VFTSS	DEG_SPOP_SBC_1	0.0556
p.E567Q	SIDM01690	Plasma Cell Myeloma	GDSC	VFTSS	DEG_SPOP_SBC_1	0.1667
p.S576N	ACH-000830	Lung Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.7069
p.A570T	ACH-000930	Breast Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.6944
p.S583F	ACH-000935	Colon/Colorectal Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.1667
p.A570V	ACH-000978	Endometrial/Uterine Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08779	Keratin, type I cytoskeletal 16	DEG_SPOP_SBC_1	443:447	VFTSS	SPOP	0.9648	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	465:469	VFTSS	SPOP	0.8674	More...
Q9ULE0	Protein WWC3	DEG_SPOP_SBC_1	727:731	VFTSS	SPOP	0.9576	More...
A5PL33	Protein KRBA1	DEG_SPOP_SBC_1	573:577	VFTSS	SPOP	0.85	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons