DegronMD - A5PL33(KRBA1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P678L	TCGA-13-0903	OV	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1111
p.P678L	DO32616	OV	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1111
p.P680L	TCGA-13-0903	OV	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1667
p.P680L	DO32616	OV	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1667
p.S576T	TCGA-34-8454	LUSC	TCGA	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6005
p.S576T	DO50094	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6005
p.A105S	TCGA-55-8204	LUAD	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1111
p.T133M	TCGA-A5-A0G2	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.7423
p.T133M	DO41235	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.7423
p.S118G	TCGA-AX-A2HJ	UCEC	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.5882
p.S118G	DO42105	UCEC	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.5882
p.R703I	TCGA-B5-A0JY	UCEC	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0556
p.R703I	DO43041	UCEC	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.0556
p.P128L	TCGA-BF-AAOX	SKCM	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1389
p.P128L	TCGA-BF-AAOX	SKCM	TCGA	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.2778
p.P128L	DO223907	SKCM	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1389
p.P128L	DO223907	SKCM	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.2778
p.G695D	TCGA-D1-A1NZ	UCEC	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.G695D	DO41536	UCEC	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.P685A	TCGA-D8-A1J8	BRCA	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.3056
p.P685A	DO1269	BRCA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.3056
p.D136N	TCGA-E6-A1LX	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.5821
p.D136N	TCGA-EC-A24G	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.5821
p.D136N	DO40996	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.5821
p.D136N	DO41020	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.5821
p.R656M	TCGA-EO-A22R	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.0556
p.R656M	DO42713	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.0556
p.V578I	TCGA-HU-A4GX	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.V578I	DO222905	BTCA	ICGC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.V578I	DO47757	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.R563Q	DO222432	ESCA	ICGC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.S569I	DO229026	LICA	ICGC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.2222
p.G691S	DO229039	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.6993
p.G695S	DO229050	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.2778
p.G698V	DO229008	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1944
p.S650Y	DO229253	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.2222
p.D146N	DO229224	THCA	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.0833
p.P128T	DO229248	THCA	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1389
p.P128T	DO229248	THCA	ICGC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.2778
p.A135V	SIDM00088	Prostate Carcinoma	GDSC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.6936
p.K104R	SIDM00842	Colorectal Carcinoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.0833
p.R587H	SIDM00778	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.R587H	SIDM01774	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.P563L	SIDM01045	Endometrial Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.P563L	EN	endometrium	COSMIC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0556
p.D119N	SIDM00801	Melanoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.6932
p.D119N	A101D	skin	COSMIC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.6932
p.S678F	SIDM00527	Colorectal Carcinoma	GDSC	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation rewiring degron network	0.1111
p.R126Q	SIDM00839	Colorectal Carcinoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1944
p.R126Q	SIDM00839	Colorectal Carcinoma	GDSC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.2222
p.R126Q	LoVo	large intestine	COSMIC	LRGLLSCLP	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1944
p.R126Q	LoVo	large intestine	COSMIC	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation rewiring degron network	0.2222
p.E567Q	SIDM01690	Plasma Cell Myeloma	GDSC	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1667
p.S576N	ACH-000830	Lung Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7069
p.T132I	ACH-000909	Endometrial/Uterine Cancer	CCLE	LATTPTDS	DEG_SCF_FBW7_1	130:137	Mutation altering degron motif	0.5966
p.A570T	ACH-000930	Breast Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation blocking phosphorylation signal	0.6944
p.S583F	ACH-000935	Colon/Colorectal Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1667
p.A570V	ACH-000978	Endometrial/Uterine Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	573:577	Mutation blocking phosphorylation signal	0.6944
p.S650N	ACH-000989	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.2222
p.E645G	ACH-000998	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.7199
p.E645G	CW-2	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.7199
p.A689G	ACH-001340	Ovarian Cancer	CCLE	PGGTPAGS	DEG_SCF_FBW7_1	686:693	Mutation altering degron motif	0.754
p.L652H	ACH-001539	Lymphoma	CCLE	PGSSS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRBA1

UniProt ID: A5PL33

Entrez ID: 84626

Protein name: Protein KRBA1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRBA1 in