DegronMD

Uniprot ID: A5PL33

Source protein: Protein KRBA1

Source gene: KRBA1

Class: DEG_SCF_FBW7_1

Location: 130:137

E3 ligase: FBXW7

DEGRON score: 0.9787

ASA_SCORE: 91.5125

COIL: 0.9621

CONS_SCORE: 0.736

DSS_SCORE: 0.6884

HELIX: 0.0248

FCONS_SCORE: 1.0883

RIG_SCORE: 0.6302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T133M	TCGA-A5-A0G2	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	0.7423
p.T133M	DO41235	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.7423
p.P128L	TCGA-BF-AAOX	SKCM	TCGA	LATTPTDS	DEG_SCF_FBW7_1	0.2778
p.P128L	DO223907	SKCM	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.2778
p.D136N	TCGA-E6-A1LX	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	0.5821
p.D136N	TCGA-EC-A24G	UCEC	TCGA	LATTPTDS	DEG_SCF_FBW7_1	0.5821
p.D136N	DO40996	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.5821
p.D136N	DO41020	UCEC	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.5821
p.D146N	DO229224	THCA	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.0833
p.P128T	DO229248	THCA	ICGC	LATTPTDS	DEG_SCF_FBW7_1	0.2778
p.A135V	SIDM00088	Prostate Carcinoma	GDSC	LATTPTDS	DEG_SCF_FBW7_1	0.6936
p.R126Q	SIDM00839	Colorectal Carcinoma	GDSC	LATTPTDS	DEG_SCF_FBW7_1	0.2222
p.R126Q	LoVo	large_intestine	COSMIC	LATTPTDS	DEG_SCF_FBW7_1	0.2222
p.T132I	ACH-000909	Endometrial/Uterine Cancer	CCLE	LATTPTDS	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PL33	Protein KRBA1	DEG_SCF_FBW7_1	130:137	LATTPTDS	FBXW7	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons