DegronMD

Uniprot ID: A5PL33

Source protein: Protein KRBA1

Source gene: KRBA1

Class: DEG_APCC_DBOX_1

Location: 113:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5487

ASA_SCORE: 86.2333

COIL: 0.8948

CONS_SCORE: 0.7953

DSS_SCORE: 0.502

HELIX: 0.066

FCONS_SCORE: 1.1878

RIG_SCORE: 0.7039

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A105S	TCGA-55-8204	LUAD	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	0.1111
p.S118G	TCGA-AX-A2HJ	UCEC	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	0.5882
p.S118G	DO42105	UCEC	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	0.5882
p.P128L	TCGA-BF-AAOX	SKCM	TCGA	LRGLLSCLP	DEG_APCC_DBOX_1	0.1389
p.P128L	DO223907	SKCM	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	0.1389
p.P128T	DO229248	THCA	ICGC	LRGLLSCLP	DEG_APCC_DBOX_1	0.1389
p.K104R	SIDM00842	Colorectal Carcinoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	0.0833
p.D119N	SIDM00801	Melanoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	0.6932
p.D119N	A101D	skin	COSMIC	LRGLLSCLP	DEG_APCC_DBOX_1	0.6932
p.R126Q	SIDM00839	Colorectal Carcinoma	GDSC	LRGLLSCLP	DEG_APCC_DBOX_1	0.1944
p.R126Q	LoVo	large_intestine	COSMIC	LRGLLSCLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PL33	Protein KRBA1	DEG_APCC_DBOX_1	113:121	LRGLLSCLP	APC,CDC20,FZR1	0.5487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons