DegronMD

Uniprot ID: A5PL33

Source protein: Protein KRBA1

Source gene: KRBA1

Class: DEG_SCF_FBW7_1

Location: 686:693

E3 ligase: FBXW7

DEGRON score: 0.9744

ASA_SCORE: 80.0375

COIL: 0.9771

CONS_SCORE: 0.5138

DSS_SCORE: 0.701

HELIX: 0.0135

FCONS_SCORE: 0.7806

RIG_SCORE: 0.4785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P678L	TCGA-13-0903	OV	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	0.1111
p.P678L	DO32616	OV	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.1111
p.P680L	TCGA-13-0903	OV	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	0.1667
p.P680L	DO32616	OV	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.1667
p.R703I	TCGA-B5-A0JY	UCEC	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	0.0556
p.R703I	DO43041	UCEC	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.0556
p.G695D	TCGA-D1-A1NZ	UCEC	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	0.2778
p.G695D	DO41536	UCEC	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.2778
p.P685A	TCGA-D8-A1J8	BRCA	TCGA	PGGTPAGS	DEG_SCF_FBW7_1	0.3056
p.P685A	DO1269	BRCA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.3056
p.G691S	DO229039	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.6993
p.G695S	DO229050	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.2778
p.G698V	DO229008	LICA	ICGC	PGGTPAGS	DEG_SCF_FBW7_1	0.1944
p.S678F	SIDM00527	Colorectal Carcinoma	GDSC	PGGTPAGS	DEG_SCF_FBW7_1	0.1111
p.A689G	ACH-001340	Ovarian Cancer	CCLE	PGGTPAGS	DEG_SCF_FBW7_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PL33	Protein KRBA1	DEG_SCF_FBW7_1	686:693	PGGTPAGS	FBXW7	0.9744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons