DegronMD - Q2M1Z3(ARHGAP31)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1353A	TCGA-05-4398	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1111
p.P1353A	DO25847	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1111
p.A1169S	TCGA-06-2566	GBM	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1389
p.A1169S	DO11507	GBM	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1389
p.N776T	TCGA-13-1509	OV	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.N776T	DO30740	OV	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.A1152S	TCGA-22-4599	LUSC	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.3056
p.A1152S	DO26945	LUSC	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.3056
p.S974N	TCGA-25-2042	OV	TCGA	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.3056
p.S974N	DO28249	OV	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.3056
p.T1239I	TCGA-28-1760	GBM	TCGA	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.7078
p.T1239I	DO13725	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.7078
p.R478C	TCGA-3A-A9I9	PAAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.R478C	DO51679	PAAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.R478C	SIDM02019	Colorectal Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.S1148C	TCGA-55-8085	LUAD	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1944
p.S1148C	TCGA-GV-A3QH	BLCA	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1944
p.S1148C	DO464	BLCA	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1944
p.S1148C	DO45326	LUAD	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1944
p.V465I	TCGA-5M-AAT6	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7076
p.V465I	DO223703	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7076
p.V1168I	TCGA-93-A4JQ	LUAD	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1667
p.V1168I	DO51195	LUAD	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1667
p.P783R	TCGA-A1-A0SN	BRCA	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.25
p.P783R	DO4299	BRCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.25
p.S503N	TCGA-A6-5656	COAD	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation blocking phosphorylation signal	0.6389
p.S503N	DO8498	COAD	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation blocking phosphorylation signal	0.6389
p.S809L	TCGA-A8-A0A6	BRCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.1944
p.S809L	DO3584	BRCA	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.1944
p.S1237N	TCGA-AA-3492	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.5958
p.S1237N	DO8224	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.5958
p.P1355T	TCGA-AJ-A3EK	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1667
p.P1355T	DO41584	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1667
p.E1223D	TCGA-AJ-A3EL	UCEC	TCGA	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation altering degron motif	0.6758
p.E1223D	DO41542	UCEC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation altering degron motif	0.6758
p.P1213S	TCGA-AP-A051	UCEC	TCGA	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.1944
p.P1213S	DO42673	UCEC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.1944
p.V498M	TCGA-AP-A0LI	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.0556
p.V498M	DO233251	GACA	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.0556
p.V498M	DO43658	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.0556
p.A1169V	TCGA-AX-A05Z	UCEC	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1389
p.A1169V	DO40884	UCEC	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.1389
p.R478H	TCGA-AZ-6601	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.R478H	TCGA-BR-8591	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.R478H	DO8119	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.R478H	DO47973	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.S457L	TCGA-B5-A11E	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.S457L	DO233859	GACA	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.S457L	DO41644	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.S476L	TCGA-B5-A1MR	UCEC	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation blocking phosphorylation signal	0.5833
p.S476L	DO229446	SKCA	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation blocking phosphorylation signal	0.5833
p.S476L	DO41758	UCEC	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation blocking phosphorylation signal	0.5833
p.P790T	TCGA-BQ-7044	KIRP	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7031
p.P790T	DO20942	KIRP	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7031
p.S973R	TCGA-BS-A0U8	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.7427
p.S973R	DO41380	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.7427
p.R1156M	TCGA-BS-A0UF	UCEC	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7521
p.R1156M	TCGA-ER-A19B	SKCM	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7521
p.R1156M	DO47491	SKCM	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7521
p.R1156M	DO41488	UCEC	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7521
p.D459N	TCGA-CA-6718	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.D459N	TCGA-CG-5728	STAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.D459N	DO7801	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.D459N	DO38619	STAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.A976V	TCGA-CK-5916	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.25
p.A976V	DO8786	COAD	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.25
p.P1355H	TCGA-CM-5861	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1667
p.P1355H	DO7918	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.1667
p.P513L	TCGA-D1-A2G0	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation altering degron motif	0.6471
p.P513L	TCGA-EO-A22U	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation altering degron motif	0.6471
p.P513L	DO43049	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation altering degron motif	0.6471
p.P513L	DO43755	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation altering degron motif	0.6471
p.Q1211K	TCGA-D3-A1QA	SKCM	TCGA	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.1389
p.Q1211K	DO47469	SKCM	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.1389
p.L781I	TCGA-D6-8569	HNSC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.1944
p.L781I	DO14454	HNSC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.1944
p.S810C	TCGA-D7-A4YT	STAD	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.2222
p.S810C	DO47723	STAD	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.2222
p.L978H	TCGA-DD-AACL	LIHC	TCGA	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1944
p.L978H	DO52208	LIHC	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1944
p.E793D	TCGA-DD-AAEH	LIHC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.6758
p.E793D	DO52272	LIHC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.6758
p.G1241E	TCGA-DU-6392	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.3056
p.G1241E	DO22237	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.3056
p.K801T	TCGA-ED-A7XP	LIHC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation substituting flanking lysine	0.2222
p.K801T	DO48562	LIHC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation substituting flanking lysine	0.2222
p.R982K	TCGA-EE-A2A2	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0833
p.R982K	DO37583	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0833
p.K463R	TCGA-F4-6806	COAD	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.K463R	DO8296	COAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.Q1160H	TCGA-FC-7961	PRAD	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.647
p.Q1160H	DO46801	PRAD	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.647
p.D1153H	TCGA-GC-A3YS	BLCA	TCGA	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7688
p.D1153H	DO850	BLCA	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7688
p.P1217S	TCGA-HU-A4GU	STAD	TCGA	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.3056
p.P1217S	DO47849	STAD	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.3056
p.P790A	TCGA-L5-A43I	ESCA	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7503
p.S827I	TCGA-L5-A8NS	ESCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation blocking phosphorylation signal	0.5833
p.D1250Y	TCGA-MN-A4N4	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0556
p.D1250Y	DO26250	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0556
p.T1367S	TCGA-NC-A5HQ	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2778
p.T1367S	DO219201	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2778
p.P804L	TCGA-Q1-A5R2	CESC	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0556
p.P804L	DO49003	CESC	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0556
p.P804L	SIDM02030	Colorectal Carcinoma	GDSC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0556
p.N458K	TCGA-UY-A78O	BLCA	TCGA	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.N458K	DO219035	BLCA	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.P804Q	TCGA-XF-AAN5	BLCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0556
p.P804Q	DO51945	BLCA	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0556
p.S1364F	TCGA-XV-AAZY	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation altering degron motif	0.7982
p.S1364F	DO219497	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation altering degron motif	0.7982
p.R1231M	DO222492	COCA	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.1111
p.R1231M	DO222492	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.S1369F	DO222884	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2222
p.G803S	DO229010	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.G803S	DO229013	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.G803S	DO229016	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.G803S	DO229003	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.G803S	DO229005	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.T789S	DO10858	ESAD	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7116
p.S468N	DO234462	ESAD	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7069
p.S468N	DO231031	LUSC	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7069
p.N479T	DO233930	GACA	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0556
p.P477L	DO45211	LIRI	ICGC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.G1225V	DO224563	LUSC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation rewiring degron network	0.2778
p.S1159F	DO222837	MELA	ICGC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7982
p.S1238L	DO228736	PRAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.7667
p.P959L	DO229453	SKCA	ICGC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0556
p.P787S	SIDM01020	Plasma Cell Myeloma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00371	Pancreatic Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00544	Neuroblastoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM01093	Cervical Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00574	Glioblastoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM01257	Hepatocellular Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00045	Gastric Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SIDM00062	Hepatocellular Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-000237	Ovarian Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-000380	Myeloma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-000556	Cervical Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-000652	Pancreatic Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-000671	Liver Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-001539	Lymphoma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-001605	Brain Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-001716	Neuroblastoma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-002019	Cervical Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-002059	Leukemia	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-002141	Gastric Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	ACH-002395	Liver Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SUIT-2	pancreas	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	no-10	central nervous system	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	GOTO	autonomic ganglia	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	HUH-6-clone5	liver	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	SiHa	cervix	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	HSC-39	stomach	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.P787S	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.5641
p.V1366M	SIDM00215	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00304	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00553	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM01005	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00465	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00282	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00596	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00214	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00280	Gastric Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00018	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM00603	Head and Neck Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM01033	Bladder Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM01776	Plasma Cell Myeloma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.V1366M	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.E1234V	SIDM00087	Plasma Cell Myeloma	GDSC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.E1234V	ACH-000817	Myeloma	CCLE	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.E1234V	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.S521G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.1667
p.S521G	ACH-001669	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.1667
p.S521G	ACH-002238	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.1667
p.S521G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.1667
p.E805V	SIDM00812	Colorectal Carcinoma	GDSC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0833
p.E805V	ACH-000236	Colon/Colorectal Cancer	CCLE	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0833
p.E805V	SW1417	large intestine	COSMIC	RTDLYID	LIG_APCC_ABBAyCdc20_2	814:820	Mutation rewiring degron network	0.0833
p.S1369T	SIDM00683	Prostate Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2222
p.S1369T	ACH-000977	lymph node	CCLE	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2222
p.S1369T	LNCaP-Clone-FGC	prostate	COSMIC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.2222
p.V969L	SIDM01056	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.6765
p.V969L	ACH-000330	Breast Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.6765
p.V969L	EFM-19	breast	COSMIC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.6765
p.N776K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.N776K	ACH-000945	Lung Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.N776K	NCI-H650	lung	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.S518Y	SIDM00032	Bladder Carcinoma	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.25
p.S518Y	ACH-000839	Bladder Cancer	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.25
p.S518Y	SCaBER	urinary tract	COSMIC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.25
p.W1155R	SIDM00032	Bladder Carcinoma	GDSC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7523
p.W1155R	SCaBER	urinary tract	COSMIC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.7523
p.P461T	SIDM00561	Other Blood Cancers	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2222
p.P461T	SIDM00566	Oral Cavity Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2222
p.P461T	SIDM01660	Kidney Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2222
p.P461T	SIDM01320	Pancreatic Carcinoma	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2222
p.P461T	SIDM01391	Neuroblastoma	GDSC	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2222
p.T960M	SIDM00217	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0833
p.T960M	ACH-000999	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0833
p.T960M	SNU-1040	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0833
p.D1368N	SIDM01617	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.25
p.D1368N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.25
p.P1352L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.0833
p.P1352L	ACH-000851	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.0833
p.L777P	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0833
p.P1154L	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation altering degron motif	0.6471
p.L1360V	SIDM01729	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.L1360V	ACH-000909	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1361:1365	Mutation rewiring degron network	0.3056
p.T507M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.3056
p.T507M	ACH-000942	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	508:515	Mutation rewiring degron network	0.3056
p.E1223G	ACH-000120	Neuroblastoma	CCLE	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation altering degron motif	0.7199
p.E1223G	CHP-212	autonomic ganglia	COSMIC	SQSSGE	DEG_Kelch_Keap1_1	1218:1223	Mutation altering degron motif	0.7199
p.T456I	ACH-000941	Endometrial/Uterine Cancer	CCLE	VFTSS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.D1164Y	ACH-001521	Skin Cancer	CCLE	DPWRVYSQDP	CBL_PTK	1153:1162	Mutation rewiring degron network	0.2778
p.P787R	ACH-002800	Unknown	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP31

UniProt ID: Q2M1Z3

Entrez ID: 57514

Protein name: Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP31 in