DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: DEG_SCF_FBW7_2

Location: 786:793

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 100.525

COIL: 0.8491

CONS_SCORE: 0.3824

DSS_SCORE: 0.753

HELIX: 0.1279

FCONS_SCORE: 1.2706

RIG_SCORE: 0.5525

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N776T	TCGA-13-1509	OV	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.N776T	DO30740	OV	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.P783R	TCGA-A1-A0SN	BRCA	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.25
p.P783R	DO4299	BRCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.25
p.P790T	TCGA-BQ-7044	KIRP	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.7031
p.P790T	DO20942	KIRP	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.7031
p.L781I	TCGA-D6-8569	HNSC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.1944
p.L781I	DO14454	HNSC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.1944
p.E793D	TCGA-DD-AAEH	LIHC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.6758
p.E793D	DO52272	LIHC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.6758
p.K801T	TCGA-ED-A7XP	LIHC	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.2222
p.K801T	DO48562	LIHC	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.2222
p.P790A	TCGA-L5-A43I	ESCA	TCGA	PPPTPLEE	DEG_SCF_FBW7_2	0.7503
p.G803S	DO229010	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.G803S	DO229013	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.G803S	DO229016	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.G803S	DO229003	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.G803S	DO229005	COCA	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.T789S	DO10858	ESAD	ICGC	PPPTPLEE	DEG_SCF_FBW7_2	0.7116
p.P787S	SIDM01020	Plasma Cell Myeloma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00371	Pancreatic Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00544	Neuroblastoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM01093	Cervical Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00574	Glioblastoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM01257	Hepatocellular Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00045	Gastric Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SIDM00062	Hepatocellular Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-000237	Ovarian Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-000380	Myeloma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-000556	Cervical Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-000652	Pancreatic Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-000671	Liver Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-001539	Lymphoma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-001605	Brain Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-001716	Neuroblastoma	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-002019	Cervical Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-002059	Leukemia	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-002141	Gastric Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	ACH-002395	Liver Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SUIT-2	pancreas	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	no-10	central_nervous_system	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	GOTO	autonomic_ganglia	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	HUH-6-clone5	liver	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	SiHa	cervix	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	HSC-39	stomach	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.P787S	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.5641
p.N776K	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.N776K	ACH-000945	Lung Cancer	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.N776K	NCI-H650	lung	COSMIC	PPPTPLEE	DEG_SCF_FBW7_2	0.0556
p.L777P	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPTPLEE	DEG_SCF_FBW7_2	0.0833
p.P787R	ACH-002800	Unknown	CCLE	PPPTPLEE	DEG_SCF_FBW7_2	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPTPLEE

Degron related mutations and impact score

Drug responses associated with ARHGAP31 mutations

All proteins holding degron of PPPTPLEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SCF_FBW7_2	786:793	PPPTPLEE	FBXW7	0.9988	More...