DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: CBL_PTK

Location: 1153:1162

E3 ligase: CBL

DEGRON score: 0.9558

ASA_SCORE: 79.74

COIL: 0.7689

CONS_SCORE: 0.2557

DSS_SCORE: 0.3111

HELIX: 0.1418

FCONS_SCORE: 1.002

RIG_SCORE: 0.8099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1169S	TCGA-06-2566	GBM	TCGA	DPWRVYSQDP	CBL_PTK	0.1389
p.A1169S	DO11507	GBM	ICGC	DPWRVYSQDP	CBL_PTK	0.1389
p.A1152S	TCGA-22-4599	LUSC	TCGA	DPWRVYSQDP	CBL_PTK	0.3056
p.A1152S	DO26945	LUSC	ICGC	DPWRVYSQDP	CBL_PTK	0.3056
p.S1148C	TCGA-55-8085	LUAD	TCGA	DPWRVYSQDP	CBL_PTK	0.1944
p.S1148C	TCGA-GV-A3QH	BLCA	TCGA	DPWRVYSQDP	CBL_PTK	0.1944
p.S1148C	DO464	BLCA	ICGC	DPWRVYSQDP	CBL_PTK	0.1944
p.S1148C	DO45326	LUAD	ICGC	DPWRVYSQDP	CBL_PTK	0.1944
p.V1168I	TCGA-93-A4JQ	LUAD	TCGA	DPWRVYSQDP	CBL_PTK	0.1667
p.V1168I	DO51195	LUAD	ICGC	DPWRVYSQDP	CBL_PTK	0.1667
p.A1169V	TCGA-AX-A05Z	UCEC	TCGA	DPWRVYSQDP	CBL_PTK	0.1389
p.A1169V	DO40884	UCEC	ICGC	DPWRVYSQDP	CBL_PTK	0.1389
p.R1156M	TCGA-BS-A0UF	UCEC	TCGA	DPWRVYSQDP	CBL_PTK	0.7521
p.R1156M	TCGA-ER-A19B	SKCM	TCGA	DPWRVYSQDP	CBL_PTK	0.7521
p.R1156M	DO47491	SKCM	ICGC	DPWRVYSQDP	CBL_PTK	0.7521
p.R1156M	DO41488	UCEC	ICGC	DPWRVYSQDP	CBL_PTK	0.7521
p.Q1160H	TCGA-FC-7961	PRAD	TCGA	DPWRVYSQDP	CBL_PTK	0.647
p.Q1160H	DO46801	PRAD	ICGC	DPWRVYSQDP	CBL_PTK	0.647
p.D1153H	TCGA-GC-A3YS	BLCA	TCGA	DPWRVYSQDP	CBL_PTK	0.7688
p.D1153H	DO850	BLCA	ICGC	DPWRVYSQDP	CBL_PTK	0.7688
p.S1159F	DO222837	MELA	ICGC	DPWRVYSQDP	CBL_PTK	0.7982
p.W1155R	SIDM00032	Bladder Carcinoma	GDSC	DPWRVYSQDP	CBL_PTK	0.7523
p.W1155R	SCaBER	urinary_tract	COSMIC	DPWRVYSQDP	CBL_PTK	0.7523
p.P1154L	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	DPWRVYSQDP	CBL_PTK	0.6471
p.D1164Y	ACH-001521	Skin Cancer	CCLE	DPWRVYSQDP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1Z3	Rho GTPase-activating protein 31	CBL_PTK	1153:1162	DPWRVYSQDP	CBL	0.9558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons