DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: DEG_Kelch_Keap1_1

Location: 1218:1223

E3 ligase: KEAP1

DEGRON score: 0.8484

ASA_SCORE: 80.5333

COIL: 0.8885

CONS_SCORE: 0.2772

DSS_SCORE: 0.747

HELIX: 0.0793

FCONS_SCORE: 0.8367

RIG_SCORE: 0.5447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1223D	TCGA-AJ-A3EL	UCEC	TCGA	SQSSGE	DEG_Kelch_Keap1_1	0.6758
p.E1223D	DO41542	UCEC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.6758
p.P1213S	TCGA-AP-A051	UCEC	TCGA	SQSSGE	DEG_Kelch_Keap1_1	0.1944
p.P1213S	DO42673	UCEC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q1211K	TCGA-D3-A1QA	SKCM	TCGA	SQSSGE	DEG_Kelch_Keap1_1	0.1389
p.Q1211K	DO47469	SKCM	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.1389
p.P1217S	TCGA-HU-A4GU	STAD	TCGA	SQSSGE	DEG_Kelch_Keap1_1	0.3056
p.P1217S	DO47849	STAD	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.3056
p.R1231M	DO222492	COCA	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.1111
p.G1225V	DO224563	LUSC	ICGC	SQSSGE	DEG_Kelch_Keap1_1	0.2778
p.E1223G	ACH-000120	Neuroblastoma	CCLE	SQSSGE	DEG_Kelch_Keap1_1	0.7199
p.E1223G	CHP-212	autonomic_ganglia	COSMIC	SQSSGE	DEG_Kelch_Keap1_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1Z3	Rho GTPase-activating protein 31	DEG_Kelch_Keap1_1	1218:1223	SQSSGE	KEAP1	0.8484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons