DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: DEG_SCF_FBW7_2

Location: 508:515

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 88.7625

COIL: 0.8331

CONS_SCORE: 0.3664

DSS_SCORE: 0.5352

HELIX: 0.1288

FCONS_SCORE: 1.0918

RIG_SCORE: 0.7227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S503N	TCGA-A6-5656	COAD	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	0.6389
p.S503N	DO8498	COAD	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	0.6389
p.V498M	TCGA-AP-A0LI	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	0.0556
p.V498M	DO233251	GACA	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	0.0556
p.V498M	DO43658	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	0.0556
p.P513L	TCGA-D1-A2G0	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	0.6471
p.P513L	TCGA-EO-A22U	UCEC	TCGA	PCRTPPKE	DEG_SCF_FBW7_2	0.6471
p.P513L	DO43049	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	0.6471
p.P513L	DO43755	UCEC	ICGC	PCRTPPKE	DEG_SCF_FBW7_2	0.6471
p.S521G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	0.1667
p.S521G	ACH-001669	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	0.1667
p.S521G	ACH-002238	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	0.1667
p.S521G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PCRTPPKE	DEG_SCF_FBW7_2	0.1667
p.S518Y	SIDM00032	Bladder Carcinoma	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	0.25
p.S518Y	ACH-000839	Bladder Cancer	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	0.25
p.S518Y	SCaBER	urinary_tract	COSMIC	PCRTPPKE	DEG_SCF_FBW7_2	0.25
p.T507M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PCRTPPKE	DEG_SCF_FBW7_2	0.3056
p.T507M	ACH-000942	Leukemia	CCLE	PCRTPPKE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SCF_FBW7_2	508:515	PCRTPPKE	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons