DegronMD

Uniprot ID: Q2M1Z3

Source protein: Rho GTPase-activating protein 31

Source gene: ARHGAP31

Class: LIG_APCC_ABBAyCdc20_2

Location: 814:820

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7023

ASA_SCORE: 84.4429

COIL: 0.543

CONS_SCORE: 0.2732

DSS_SCORE: 0.5749

HELIX: 0.3996

FCONS_SCORE: 0.9924

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S809L	TCGA-A8-A0A6	BRCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.1944
p.S809L	DO3584	BRCA	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.1944
p.S810C	TCGA-D7-A4YT	STAD	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.2222
p.S810C	DO47723	STAD	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.2222
p.S827I	TCGA-L5-A8NS	ESCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.5833
p.P804L	TCGA-Q1-A5R2	CESC	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.P804L	DO49003	CESC	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.P804L	SIDM02030	Colorectal Carcinoma	GDSC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.P804Q	TCGA-XF-AAN5	BLCA	TCGA	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.P804Q	DO51945	BLCA	ICGC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0556
p.E805V	SIDM00812	Colorectal Carcinoma	GDSC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0833
p.E805V	ACH-000236	Colon/Colorectal Cancer	CCLE	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0833
p.E805V	SW1417	large_intestine	COSMIC	RTDLYID	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1Z3	Rho GTPase-activating protein 31	LIG_APCC_ABBAyCdc20_2	814:820	RTDLYID	APC,CDC20,FZR1	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons