DegronMD

Uniprot ID: Q9ULE0

Source protein: Protein WWC3

Source gene: WWC3

Class: DEG_APCC_DBOX_1

Location: 454:462

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.992

ASA_SCORE: 83.3556

COIL: 0.8296

CONS_SCORE: 0.3519

DSS_SCORE: 0.5964

HELIX: 0.148

FCONS_SCORE: 1.0112

RIG_SCORE: 0.5433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D444Y	TCGA-06-5416	GBM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556
p.D444Y	DO10880	GBM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.0556
p.T445M	TCGA-AA-3861	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.5278
p.T445M	TCGA-AA-3864	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.5278
p.T445M	DO8490	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.5278
p.T445M	DO9562	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.5278
p.T445M	ACH-001719	Ovarian Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	0.5278
p.R455H	TCGA-B5-A11I	UCEC	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.8244
p.R455H	DO41229	UCEC	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.8244
p.R455C	TCGA-EE-A29A	SKCM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.8301
p.R455C	DO37416	SKCM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.8301
p.S466L	TCGA-G4-6586	COAD	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.2222
p.S466L	DO9698	COAD	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.2222
p.S448F	TCGA-GN-A4U3	SKCM	TCGA	SRSSLSSLS	DEG_APCC_DBOX_1	0.1667
p.S448F	DO219484	SKCM	ICGC	SRSSLSSLS	DEG_APCC_DBOX_1	0.1667
p.S451L	SIDM00392	Melanoma	GDSC	SRSSLSSLS	DEG_APCC_DBOX_1	0.25
p.S451L	ACH-000810	Skin Cancer	CCLE	SRSSLSSLS	DEG_APCC_DBOX_1	0.25
p.S451L	SK-MEL-30	skin	COSMIC	SRSSLSSLS	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons