DegronMD

Uniprot ID: Q6AWC2

Source protein: Protein WWC2

Source gene: WWC2

Class: DEG_SPOP_SBC_1

Location: 569:573

E3 ligase: SPOP

DEGRON score: 0.827

ASA_SCORE: 62.62

COIL: 0.7862

CONS_SCORE: 0.2309

DSS_SCORE: 0.3529

HELIX: 0.1268

FCONS_SCORE: 0.7168

RIG_SCORE: 0.6249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H579R	TCGA-66-2758	LUSC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1667
p.L578F	TCGA-EO-A22U	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1944
p.S577F	TCGA-EY-A215	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2222
p.T567M	TCGA-VQ-A8P2	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.P570T	DO42673	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7031
p.G566C	SIDM00220	Ovarian Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.25
p.G566C	ACH-000962	Ovarian Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.25
p.G566C	ACH-001145	Ovarian Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.25
p.G566C	OC-314	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons